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• W2068904023 abstract "Awareness is growing that tuberculosis is a major cause of disease and death in children from areas endemic with tuberculosis, but its contribution is poorly quantified because of diagnostic difficulties in resource-limited settings. 1 Marais BJ Graham SM Maeurer M Zumla A Progress and challenges in childhood tuberculosis. Lancet Infect Dis. 2013; 13: 287-289 Summary Full Text Full Text PDF PubMed Scopus (54) Google Scholar Globally, in 2011, an estimated 1·3 million deaths in children were attributed to pneumonia. 2 Liu L Johnson HL Cousens S et al. Global, regional and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012; 379: 2151-2161 Summary Full Text Full Text PDF PubMed Scopus (2605) Google Scholar Most of these deaths occurred in areas endemic with tuberculosis, where the actual cause of death was rarely verified. Autopsy studies identified tuberculosis in 11% of children infected with HIV, and 8% of children not infected with HIV who died from respiratory disease in five African countries. 3 Bates M Mudenda V Mwaba P Zumla A Deaths due to respiratory tract infections in Africa: a review of autopsy studies. Curr Opin Pulm Med. 2013; 19: 229-237 Crossref PubMed Scopus (57) Google Scholar Tuberculosis might also be an underlying cause of death in children dying from meningitis, sepsis, HIV/AIDS, or severe malnutrition, and its relative contribution to child morbidity and mortality is likely to increase if widespread rollout of Haemophilus influenza type B, pneumococcal, and rotavirus vaccines reduces the effect of these diseases. 4 Graham SM Sismanidis C Menzies HJ Marais BJ Detjen AK Black RE Importance of tuberculosis control to address child survival. Lancet. 2014; (published online March 24.)http://dx.doi.org/10.1016/S0140-6736(14)60420-7 PubMed Google Scholar Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimatesOur estimates underscore that many cases of tuberculosis and multidrug-resistant tuberculosis disease are not being detected in children. Future estimates can be refined as more and better tuberculosis data and new diagnostic instruments become available. Full-Text PDF Importance of tuberculosis control to address child survivalTuberculosis commonly affects young children (<5 years) in countries that have high rates of child mortality.1 The global public health focus to control tuberculosis has traditionally aimed to reduce transmission through early case-finding and effective treatment of the most infectious cases. Young children have historically been excluded from this focus, since their contribution to tuberculosis transmission is believed to be small. In the past decade, national tuberculosis programmes in high-burden settings have given increased attention to the challenges of childhood tuberculosis. Full-Text PDF" @default.
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• W2068904023 date "2014-05-01" @default.
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• W2068904023 title "Quantifying the tuberculosis disease burden in children" @default.
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• W2068904023 doi "https://doi.org/10.1016/s0140-6736(14)60489-x" @default.
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