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- W2068904770 abstract "Cystic fibrosis is a multi-system lethal genetic disorder. Mutations in the gene that encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) are the basis of this disorder. Currently, a variety of CF mouse models have been developed for in-depth studies. They provide significant insight into the pathophysiology; however, these models do not always mimic the human disease. In this review we will summarize the available models and highlight the characteristics that have made them important tools for advancing our understanding of CF pathophysiology and for drug development." @default.
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- W2068904770 date "2009-06-01" @default.
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- W2068904770 title "How useful are cystic fibrosis mouse models?" @default.
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- W2068904770 doi "https://doi.org/10.1016/j.ddmod.2009.03.009" @default.
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