FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068909255> ?p ?o ?g. }

• W2068909255 endingPage "3490" @default.
• W2068909255 startingPage "3486" @default.
• W2068909255 abstract "Posttransplantation recurrence of focal segmental glomerulosclerosis (FSGS) is one of the most disarming events in human pathology with important social and psychological consequences. It usually occurs in 30% to 50% of patients affected by the primary form of the disease with an abrupt onset in the majority of cases occurring within 1 month of the transplantation. Prediction of recurrent cases and early therapy with plasmapheresis are the main goals of the therapy. Although the mechanism of posttransplantation recurrence is still obscure, it has been proposed to be of a multifactorial origin, in which plasma factors determine the shedding of proteins of the slit-diaphragm, such as nephrin and podocin, with structural alterations of the ultra-filtering unit of the glomerulus. Low resynthesis of podocin and/or haplo-insufficiency due to heterozygous mutations should represent significant predisposing factors to proteinuria. In this review, the role of podocin in posttransplantation recurrence will be evaluated focusing on the possibility that resynthesis of the protein could represent a key step also for stable normalization of the renal filter. The recent characterization of the podocin promoter cis- and trans- acting elements and the possibility to characterize low- and high-podocin producer haplotypes offer opportunities to evaluate the capacity for podocin resynthesis in the donor kidney. A review of the literature on posttransplantation recurrence of FSGS in patients originally carrying homozygous and/or heterozygous NPHS2 mutations supports the general idea of a multifactorial origin of the primary disease that can be extended to the pathogenesis of posttransplantation recurrence." @default.
• W2068909255 created "2016-06-24" @default.
• W2068909255 creator A5026725672 @default.
• W2068909255 creator A5039683551 @default.
• W2068909255 creator A5043665583 @default.
• W2068909255 creator A5059655083 @default.
• W2068909255 creator A5070657830 @default.
• W2068909255 date "2006-12-01" @default.
• W2068909255 modified "2023-09-27" @default.
• W2068909255 title "Podocin-Related Mechanisms in Posttransplantation Recurrence of Focal Segmental Glomerulsclerosis" @default.
• W2068909255 cites W1540786657 @default.
• W2068909255 cites W1960285963 @default.
• W2068909255 cites W1981541679 @default.
• W2068909255 cites W1987933521 @default.
• W2068909255 cites W1988399710 @default.
• W2068909255 cites W1990488096 @default.
• W2068909255 cites W1993387604 @default.
• W2068909255 cites W2005043762 @default.
• W2068909255 cites W2007978030 @default.
• W2068909255 cites W2017844423 @default.
• W2068909255 cites W2018215777 @default.
• W2068909255 cites W2022271802 @default.
• W2068909255 cites W2023116194 @default.
• W2068909255 cites W2029163547 @default.
• W2068909255 cites W2031085640 @default.
• W2068909255 cites W2031098987 @default.
• W2068909255 cites W2042604174 @default.
• W2068909255 cites W2044100552 @default.
• W2068909255 cites W2063411993 @default.
• W2068909255 cites W2081756875 @default.
• W2068909255 cites W2089391563 @default.
• W2068909255 cites W2092780150 @default.
• W2068909255 cites W2110230080 @default.
• W2068909255 cites W2112549609 @default.
• W2068909255 cites W2114889093 @default.
• W2068909255 cites W2121048650 @default.
• W2068909255 cites W2123873294 @default.
• W2068909255 cites W2126226666 @default.
• W2068909255 cites W2126712474 @default.
• W2068909255 cites W2129301826 @default.
• W2068909255 cites W2133176024 @default.
• W2068909255 cites W2133282268 @default.
• W2068909255 cites W2135679847 @default.
• W2068909255 cites W2142421383 @default.
• W2068909255 cites W2143134436 @default.
• W2068909255 cites W2148572488 @default.
• W2068909255 cites W2153658205 @default.
• W2068909255 cites W2157895568 @default.
• W2068909255 cites W2158393830 @default.
• W2068909255 cites W2162995559 @default.
• W2068909255 cites W2167051832 @default.
• W2068909255 cites W2323753285 @default.
• W2068909255 cites W2412304226 @default.
• W2068909255 cites W4231951653 @default.
• W2068909255 cites W4234759211 @default.
• W2068909255 cites W4253484688 @default.
• W2068909255 doi "https://doi.org/10.1016/j.transproceed.2006.10.004" @default.
• W2068909255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175312" @default.
• W2068909255 hasPublicationYear "2006" @default.
• W2068909255 type Work @default.
• W2068909255 sameAs 2068909255 @default.
• W2068909255 citedByCount "9" @default.
• W2068909255 countsByYear W20689092552012 @default.
• W2068909255 countsByYear W20689092552013 @default.
• W2068909255 countsByYear W20689092552016 @default.
• W2068909255 countsByYear W20689092552019 @default.
• W2068909255 crossrefType "journal-article" @default.
• W2068909255 hasAuthorship W2068909255A5026725672 @default.
• W2068909255 hasAuthorship W2068909255A5039683551 @default.
• W2068909255 hasAuthorship W2068909255A5043665583 @default.
• W2068909255 hasAuthorship W2068909255A5059655083 @default.
• W2068909255 hasAuthorship W2068909255A5070657830 @default.
• W2068909255 hasConcept C126322002 @default.
• W2068909255 hasConcept C142724271 @default.
• W2068909255 hasConcept C203014093 @default.
• W2068909255 hasConcept C2776855237 @default.
• W2068909255 hasConcept C2777146197 @default.
• W2068909255 hasConcept C2778415529 @default.
• W2068909255 hasConcept C2779561371 @default.
• W2068909255 hasConcept C2780091579 @default.
• W2068909255 hasConcept C2780368995 @default.
• W2068909255 hasConcept C2911091166 @default.
• W2068909255 hasConcept C54847362 @default.
• W2068909255 hasConcept C71924100 @default.
• W2068909255 hasConceptScore W2068909255C126322002 @default.
• W2068909255 hasConceptScore W2068909255C142724271 @default.
• W2068909255 hasConceptScore W2068909255C203014093 @default.
• W2068909255 hasConceptScore W2068909255C2776855237 @default.
• W2068909255 hasConceptScore W2068909255C2777146197 @default.
• W2068909255 hasConceptScore W2068909255C2778415529 @default.
• W2068909255 hasConceptScore W2068909255C2779561371 @default.
• W2068909255 hasConceptScore W2068909255C2780091579 @default.
• W2068909255 hasConceptScore W2068909255C2780368995 @default.
• W2068909255 hasConceptScore W2068909255C2911091166 @default.
• W2068909255 hasConceptScore W2068909255C54847362 @default.
• W2068909255 hasConceptScore W2068909255C71924100 @default.
• W2068909255 hasIssue "10" @default.
• W2068909255 hasLocation W20689092551 @default.

• next