FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068909778> ?p ?o ?g. }

• W2068909778 endingPage "9567" @default.
• W2068909778 startingPage "9560" @default.
• W2068909778 abstract "α-Dystroglycan (α-DG) is a membrane-associated glycoprotein that interacts with several extracellular matrix proteins, including laminin and agrin. Aberrant glycosylation of α-DG disrupts its interaction with ligands and causes a certain type of muscular dystrophy commonly referred to as dystroglycanopathy. It has been reported that a unique O-mannosyl tetrasaccharide (Neu5Ac-α2,3-Gal-β1,4-GlcNAc-β1,2-Man) and a phosphodiester-linked modification on O-mannose play important roles in the laminin binding activity of α-DG. In this study, we use several dystroglycanopathy mouse models to demonstrate that, in addition to fukutin and LARGE, FKRP (fukutin-related protein) is also involved in the post-phosphoryl modification of O-mannose on α-DG. Furthermore, we have found that the glycosylation status of α-DG in lung and testis is minimally affected by defects in fukutin, LARGE, or FKRP. α-DG prepared from wild-type lung- or testis-derived cells lacks the post-phosphoryl moiety and shows little laminin-binding activity. These results show that FKRP is involved in post-phosphoryl modification rather than in O-mannosyl tetrasaccharide synthesis. Our data also demonstrate that post-phosphoryl modification not only plays critical roles in the pathogenesis of dystroglycanopathy but also is a key determinant of α-DG functional expression as a laminin receptor in normal tissues and cells." @default.
• W2068909778 created "2016-06-24" @default.
• W2068909778 creator A5004661108 @default.
• W2068909778 creator A5006600392 @default.
• W2068909778 creator A5010957149 @default.
• W2068909778 creator A5026422515 @default.
• W2068909778 creator A5035924543 @default.
• W2068909778 creator A5037417355 @default.
• W2068909778 creator A5043126305 @default.
• W2068909778 creator A5060849895 @default.
• W2068909778 creator A5062685178 @default.
• W2068909778 creator A5068370797 @default.
• W2068909778 creator A5077627550 @default.
• W2068909778 creator A5081094280 @default.
• W2068909778 creator A5090371447 @default.
• W2068909778 date "2012-03-01" @default.
• W2068909778 modified "2023-10-04" @default.
• W2068909778 title "Absence of Post-phosphoryl Modification in Dystroglycanopathy Mouse Models and Wild-type Tissues Expressing Non-laminin Binding Form of α-Dystroglycan" @default.
• W2068909778 cites W1528429662 @default.
• W2068909778 cites W1572408887 @default.
• W2068909778 cites W1963757547 @default.
• W2068909778 cites W1968666078 @default.
• W2068909778 cites W1972695095 @default.
• W2068909778 cites W1975861627 @default.
• W2068909778 cites W1981004520 @default.
• W2068909778 cites W1981447099 @default.
• W2068909778 cites W1981797549 @default.
• W2068909778 cites W1981850472 @default.
• W2068909778 cites W1999731543 @default.
• W2068909778 cites W1999765737 @default.
• W2068909778 cites W2007755400 @default.
• W2068909778 cites W2015968948 @default.
• W2068909778 cites W2022146692 @default.
• W2068909778 cites W2047041038 @default.
• W2068909778 cites W2047850625 @default.
• W2068909778 cites W2056602792 @default.
• W2068909778 cites W2061697489 @default.
• W2068909778 cites W2062628051 @default.
• W2068909778 cites W2065609600 @default.
• W2068909778 cites W2073724408 @default.
• W2068909778 cites W2081042973 @default.
• W2068909778 cites W2087362044 @default.
• W2068909778 cites W2088263287 @default.
• W2068909778 cites W2095245008 @default.
• W2068909778 cites W2099297860 @default.
• W2068909778 cites W2099609870 @default.
• W2068909778 cites W2107712284 @default.
• W2068909778 cites W2111591442 @default.
• W2068909778 cites W2123191172 @default.
• W2068909778 cites W2124032562 @default.
• W2068909778 cites W2124390040 @default.
• W2068909778 cites W2128173275 @default.
• W2068909778 cites W2135383773 @default.
• W2068909778 cites W2149050786 @default.
• W2068909778 cites W2151292262 @default.
• W2068909778 cites W2153776008 @default.
• W2068909778 cites W2154637882 @default.
• W2068909778 cites W2156863768 @default.
• W2068909778 cites W2160038542 @default.
• W2068909778 cites W4234729921 @default.
• W2068909778 doi "https://doi.org/10.1074/jbc.m111.271767" @default.
• W2068909778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3308745" @default.
• W2068909778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22270369" @default.
• W2068909778 hasPublicationYear "2012" @default.
• W2068909778 type Work @default.
• W2068909778 sameAs 2068909778 @default.
• W2068909778 citedByCount "30" @default.
• W2068909778 countsByYear W20689097782012 @default.
• W2068909778 countsByYear W20689097782013 @default.
• W2068909778 countsByYear W20689097782014 @default.
• W2068909778 countsByYear W20689097782015 @default.
• W2068909778 countsByYear W20689097782016 @default.
• W2068909778 countsByYear W20689097782017 @default.
• W2068909778 countsByYear W20689097782018 @default.
• W2068909778 countsByYear W20689097782021 @default.
• W2068909778 crossrefType "journal-article" @default.
• W2068909778 hasAuthorship W2068909778A5004661108 @default.
• W2068909778 hasAuthorship W2068909778A5006600392 @default.
• W2068909778 hasAuthorship W2068909778A5010957149 @default.
• W2068909778 hasAuthorship W2068909778A5026422515 @default.
• W2068909778 hasAuthorship W2068909778A5035924543 @default.
• W2068909778 hasAuthorship W2068909778A5037417355 @default.
• W2068909778 hasAuthorship W2068909778A5043126305 @default.
• W2068909778 hasAuthorship W2068909778A5060849895 @default.
• W2068909778 hasAuthorship W2068909778A5062685178 @default.
• W2068909778 hasAuthorship W2068909778A5068370797 @default.
• W2068909778 hasAuthorship W2068909778A5077627550 @default.
• W2068909778 hasAuthorship W2068909778A5081094280 @default.
• W2068909778 hasAuthorship W2068909778A5090371447 @default.
• W2068909778 hasBestOaLocation W20689097781 @default.
• W2068909778 hasConcept C108625454 @default.
• W2068909778 hasConcept C170493617 @default.
• W2068909778 hasConcept C185592680 @default.
• W2068909778 hasConcept C189165786 @default.
• W2068909778 hasConcept C2775887612 @default.
• W2068909778 hasConcept C2777313579 @default.
• W2068909778 hasConcept C2778384963 @default.
• W2068909778 hasConcept C2779024559 @default.

• next