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• W2068909924 abstract "Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans. A large body of biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex. However, until recently there has been no direct demonstration that heparan is required for the biological activity of FGF in a developmental system in vivo. A recent paper by Lin et al.(1) has broken through this barrier to demonstrate that heparan sulfate is essential for FGF function during Drosophila development. The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000." @default.
• W2068909924 created "2016-06-24" @default.
• W2068909924 creator A5005933126 @default.
• W2068909924 date "2000-01-31" @default.
• W2068909924 modified "2023-10-10" @default.
• W2068909924 title "FGFs, heparan sulfate and FGFRs: complex interactions essential for development" @default.
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• W2068909924 doi "https://doi.org/10.1002/(sici)1521-1878(200002)22:2<108::aid-bies2>3.0.co;2-m" @default.
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