FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068911813> ?p ?o ?g. }

• W2068911813 endingPage "454" @default.
• W2068911813 startingPage "453" @default.
• W2068911813 abstract "Although gentamicin pharmacokinetics during conventional hemodialysis (C-HD) have been investigated,1, 2 there is no information regarding gentamicin removal during on-line hemodiafiltration (OL-HDF). Here we present the results of a study that was undertaken to clarify this issue, after receiving the approval of the hospital scientific and ethic committees and the consent of patients. In 8 stable chronic hemodialysis patients undergoing OL-HDF (group A), and 6 other patients undergoing C-HD (group B), a single dose of 2 mg/kg gentamicin was administered intravenously over a period of 10 min. None of the patients had received gentamicin during the previous month, none had significant residual renal function, and all had well-functioning vascular accesses. Patient demographics are shown in Table I. Blood samples for gentamicin serum level measurements were drawn before its administration (time 0 = T0), 1 1/2 hr later, immediately before the start of the dialysis session (time 1 = T1), and 3 min after the end of the session (time 2 = T2). Serum was stored at −4°C until measurement. Gentamicin serum levels were measured on an AxSYM-FPIA analyzer (Abbott, Abbott Park, Ill). The dialysis session length was 240 min in all patients. The dialyzer blood flow rate was maintained between 330 and 350 mL/min, while the dialysate flow rate was kept at 700 mL/min in all patients. ON-HDF was performed using high-flux polyester-polymer-alloy (PEPA) dialyzers (FDX18GW, surface area 1.8 m2, Nikkiso, Tokyo, Japan) with a total of 18 L replacement fluid administered post-filter, while C-HD was performed using low-flux polysulfone dialyzers (Fresenius-F8, surface area 1.8 m2, Fresenius Medical Care, Bad Homburg, Germany). BUN and creatinine levels were also measured using conventional biochemical methods at times T1 and T2. Table II shows the results of the study. None of the parameters measured differed significantly between groups A and B, with the exception of gentamicin serum levels at the end of the study sessions. These end-dialysis gentamicin levels were significantly lower in group A patients compared with group B patients (1.2 ± 0.3 ng/ml vs. 2.3 ± 0.5 ng/mL, respectively; p < .001). No correlation was found between BUN or creatinine serum levels changes and the corresponding gentamicin changes during the study sessions. Although our investigation is not a detailed pharmacokinetic study, it clearly indicates that gentamicin is removed much more efficiently during ON-HDF compared with C-HD. This is an expected outcome since ON-HDF is performed with high-flux dialyzers, and the method used (diffusion plus convection) is more efficient than C-HD (diffusion only) in removing middle-sized molecular substances such as aminoglycosides (MW approximately 500 Da).3 It has been reported that high-flux polysulfone dialyzers permit better removal of gentamicin.4 However, it is not clear from our study whether the dialyzer, the method, or both are responsible for this difference. Although blood level monitoring is the gold standard method to adjust gentamicin dose in patients with end-stage renal disease undergoing dialysis, the difference between ON-HDF and C-HD should be kept in mind, especially when gentamicin is administered before dialysis, as has been proposed recently.5 More studies are needed to clarify the cause of lower gentamicin serum levels at the end of ON-HDF compared with C-HD, and to determine practical guidelines for gentamicin administration in patients undergoing OL-HDF." @default.
• W2068911813 created "2016-06-24" @default.
• W2068911813 creator A5007268495 @default.
• W2068911813 creator A5018601212 @default.
• W2068911813 creator A5022341608 @default.
• W2068911813 creator A5064150520 @default.
• W2068911813 creator A5070170171 @default.
• W2068911813 creator A5082405036 @default.
• W2068911813 date "2010-10-01" @default.
• W2068911813 modified "2023-09-27" @default.
• W2068911813 title "On-line hemodiafiltration reduces serum gentamicin levels much more efficiently than conventional hemodialysis" @default.
• W2068911813 cites W2001848268 @default.
• W2068911813 cites W2011219480 @default.
• W2068911813 cites W2030168088 @default.
• W2068911813 cites W2058335113 @default.
• W2068911813 doi "https://doi.org/10.1002/dat.20482" @default.
• W2068911813 hasPublicationYear "2010" @default.
• W2068911813 type Work @default.
• W2068911813 sameAs 2068911813 @default.
• W2068911813 citedByCount "2" @default.
• W2068911813 countsByYear W20689118132015 @default.
• W2068911813 countsByYear W20689118132017 @default.
• W2068911813 crossrefType "journal-article" @default.
• W2068911813 hasAuthorship W2068911813A5007268495 @default.
• W2068911813 hasAuthorship W2068911813A5018601212 @default.
• W2068911813 hasAuthorship W2068911813A5022341608 @default.
• W2068911813 hasAuthorship W2068911813A5064150520 @default.
• W2068911813 hasAuthorship W2068911813A5070170171 @default.
• W2068911813 hasAuthorship W2068911813A5082405036 @default.
• W2068911813 hasBestOaLocation W20689118131 @default.
• W2068911813 hasConcept C112705442 @default.
• W2068911813 hasConcept C126322002 @default.
• W2068911813 hasConcept C126894567 @default.
• W2068911813 hasConcept C141071460 @default.
• W2068911813 hasConcept C2775832221 @default.
• W2068911813 hasConcept C2778063415 @default.
• W2068911813 hasConcept C2779978075 @default.
• W2068911813 hasConcept C42219234 @default.
• W2068911813 hasConcept C501593827 @default.
• W2068911813 hasConcept C71924100 @default.
• W2068911813 hasConcept C86803240 @default.
• W2068911813 hasConcept C89423630 @default.
• W2068911813 hasConceptScore W2068911813C112705442 @default.
• W2068911813 hasConceptScore W2068911813C126322002 @default.
• W2068911813 hasConceptScore W2068911813C126894567 @default.
• W2068911813 hasConceptScore W2068911813C141071460 @default.
• W2068911813 hasConceptScore W2068911813C2775832221 @default.
• W2068911813 hasConceptScore W2068911813C2778063415 @default.
• W2068911813 hasConceptScore W2068911813C2779978075 @default.
• W2068911813 hasConceptScore W2068911813C42219234 @default.
• W2068911813 hasConceptScore W2068911813C501593827 @default.
• W2068911813 hasConceptScore W2068911813C71924100 @default.
• W2068911813 hasConceptScore W2068911813C86803240 @default.
• W2068911813 hasConceptScore W2068911813C89423630 @default.
• W2068911813 hasIssue "10" @default.
• W2068911813 hasLocation W20689118131 @default.
• W2068911813 hasOpenAccess W2068911813 @default.
• W2068911813 hasPrimaryLocation W20689118131 @default.
• W2068911813 hasRelatedWork W113810927 @default.
• W2068911813 hasRelatedWork W1988244336 @default.
• W2068911813 hasRelatedWork W2076376032 @default.
• W2068911813 hasRelatedWork W2147391611 @default.
• W2068911813 hasRelatedWork W2363908136 @default.
• W2068911813 hasRelatedWork W2412982254 @default.
• W2068911813 hasRelatedWork W3146460242 @default.
• W2068911813 hasRelatedWork W40023729 @default.
• W2068911813 hasRelatedWork W4309119263 @default.
• W2068911813 hasRelatedWork W2304521611 @default.
• W2068911813 hasVolume "39" @default.
• W2068911813 isParatext "false" @default.
• W2068911813 isRetracted "false" @default.
• W2068911813 magId "2068911813" @default.
• W2068911813 workType "article" @default.