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• W2068921856 startingPage "949" @default.
• W2068921856 abstract "We synthesized a new chalcone (4,2’-dihydroxy-3methoxy-5-bromine chalcone; C) and structurally identified it via infrared spectrometry (IR), 1H-NMR, mass spectrometry (MS) and element analysis (EA). C was confirmed to be highly potent in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Tests of anti-free radical activity in response to oxidative stress in mice revealed that C could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in a free-radical–injured scopolamine-induced Alzheimer’s model. Further behavioral tests with the Morris water maze showed that C could antagonize the learning impairments in the Alzheimer’s model, which suggests that C has a potential role in Alzheimer’s disease." @default.
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• W2068921856 date "2012-01-01" @default.
• W2068921856 modified "2023-10-14" @default.
• W2068921856 title "The Synthesis of a Novel Chalcone and Evaluation for Anti-free Radical Activity and Antagonizing the Learning Impairments in Alzheimer’s Model" @default.
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• W2068921856 doi "https://doi.org/10.1159/000188336" @default.
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