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• W2068922034 endingPage "137" @default.
• W2068922034 startingPage "129" @default.
• W2068922034 abstract "Radionuclide injury to the lung has been studied in rats, hamsters, dogs, mice and baboons. Exposure of the lung to high dose levels of radionuclides produces a spectrum of progressively more severe functional and morphological changes, ranging from radiation pneumonitis and fibrosis to lung tumors. These changes are somewhat similar for different species. Their severity can be related to the absorbed radiation dose (measured in rads) produced by alpha, beta or gamma radiation emanating from various deposited radionuclides. The chemicophysical forms of radionuclides and spatial-temporal factors are also important variables. As with other forms of injury to the lung, repair attempts are highlighted by fibrosis and proliferation of pulmonary epithelium. Lung tumors are the principal late effect observed in experimental animals following pulmonary deposition of radionuclides at dose levels that do not result in early deaths from radiation pneumonitis or fibrosis. The predominant lung tumors described have been of epithelial origin and have been classified, in decreasing frequency of occurrence, as adenocarcinoma, bronchioloalveolar carcinoma, epidermoid carcinomas and combined epidermoid and adenocarcinoma. Mesothelioma and fibrosarcoma have been observed in rats, but less commonly in other species. Hemangiosarcomas were frequency observed in dogs exposed to beta-gamma emitters, and occasionally in rats exposed to alpha emitters. These morphologic changes in the lungs of experimental animals were reviewed and issues relevant to the prediction of human hazards discussed." @default.
• W2068922034 created "2016-06-24" @default.
• W2068922034 creator A5014997345 @default.
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• W2068922034 date "1984-04-01" @default.
• W2068922034 modified "2023-09-27" @default.
• W2068922034 title "Radionuclide injury to the lung." @default.
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• W2068922034 doi "https://doi.org/10.1289/ehp.8455129" @default.
• W2068922034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568356" @default.
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