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- W2068923044 abstract "Apolipoprotein E, the most common apolipoprotein found in the brain, is linked to several pathologies like Alzheimer's disease. Apolipoprotein E directly binds to μ-amyloid with a strong affinity. Myeloperoxidase, a protein secreted by neutrophils and involved in the inflammatory process, is also present in the brain. In vitro myeloperoxidase oxidation of recombinant human apolipoprotein E leads to fragmentation of the protein with low concentrations of hydrogen peroxide and polymerization with higher concentrations. Comparison with bovine serum albumin shows a higher susceptibility of apolipoprotein E to myeloperoxidase oxidation, which may have importance in the Alzheimer's disease process." @default.
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- W2068923044 date "1996-05-01" @default.
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- W2068923044 title "Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain" @default.
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- W2068923044 doi "https://doi.org/10.1016/0304-3940(96)12661-6" @default.
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