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- W2068932587 abstract "To the Editor.— Mendel et al 1 present placebo-controlled, double-blind, crossover study of the effects of the treatment of pain with the combination of amitriptyline and fluphenazine in six patients with diabetic neuropathy, concluding that a placebo response was seen, but no additional effect of amitriptyline and fluphenazine was seen. The study is studded with major flaws, to the extent that its conclusions are vitiated. No objective assessment of the neuropathy was made. Since cutaneous hypersensitivity and evoked dysesthesia, characteristic of painful diabetic neuropathy, 2 were not described, the group of patients studied is not comparable with the population of individuals with the disorder. Furthermore, since none of the patients in the study exhibited signs or symptoms of depression, atypicality is further ensured. Previous studies 3-5 were concerned with patients refractory to other modes of treatment. Mendel et al 1 provide no information regarding prior response to any treatment." @default.
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- W2068932587 date "1986-08-08" @default.
- W2068932587 modified "2023-10-18" @default.
- W2068932587 title "Amitriptyline and Fluphenazine for Painful Diabetic Neuropathy" @default.
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- W2068932587 doi "https://doi.org/10.1001/jama.1986.03380060038012" @default.
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