Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068933036> ?p ?o ?g. }
- W2068933036 endingPage "175" @default.
- W2068933036 startingPage "161" @default.
- W2068933036 abstract "We have retrospectively investigated patients with hepatocellular carcinoma (HCC) (912 cases) treated in the Affiliated Hospitals of Keio University (the Keio Association for the Study of Liver Diseases: KASLD) and here we review the recent diagnosis and treatment of HCC. HCC is a major cause of death in Japan and a major etiology of this disease is chronic viral infection such as hepatitis C virus (HCV) and hepatitis B virus (HBV). Screening of HCC by imaging studies and measurement of serum tumor markers successfully prolonged survival of the patients in Japan. The prognosis of this disease has been determined by both tumor factors and degree of liver function, and its staging is usually established with a recent system such as Japan Integrated Staging Score (JIS). The 5-year survival rate of JIS stage 0, 1, 2 and 3 were 68.3%, 51.9%, 25.8% and 16.6%, respectively in our cohort. Multivariate analysis using Cox proportional hazard models showed that age (>65), HCV infection, tumor number, TB (>1.0), AFP (>20) and PIVKA-II (>40) were significant factors affecting survival among the entire patients. Major treatment strategies are hepatic resection, radio frequency ablation and transarterial chemo-embolization, but alternative treatments such as radiation, chemotherapy, and their combination have been used to reduce tumor sizes resulting prolongation of the survival or maintenance of patients' quality of life, while liver transplantation has not been popular in Japan. However, the overall survival continues to decrease from year to year, and does not show a plateau phase in Kaplan-Mayer curve. These results suggest that the best way to improve survival can be achieved by prevention of the disease. Antiviral therapies have decreased the incidence of HCC, indicating that treatment for chronic hepatitis is the best way to prevent HCC development at present." @default.
- W2068933036 created "2016-06-24" @default.
- W2068933036 creator A5016331106 @default.
- W2068933036 creator A5022393845 @default.
- W2068933036 creator A5026205612 @default.
- W2068933036 creator A5055701033 @default.
- W2068933036 creator A5056836514 @default.
- W2068933036 creator A5072237436 @default.
- W2068933036 creator A5087503433 @default.
- W2068933036 creator A5090834989 @default.
- W2068933036 date "2009-01-01" @default.
- W2068933036 modified "2023-09-27" @default.
- W2068933036 title "Hepatocellular Carcinoma in Keio Affiliated Hospitals — Diagnosis, Treatment, and Prognosis of this Disease —" @default.
- W2068933036 cites W1508131006 @default.
- W2068933036 cites W1549556509 @default.
- W2068933036 cites W175518023 @default.
- W2068933036 cites W1781229955 @default.
- W2068933036 cites W1965536826 @default.
- W2068933036 cites W1965881995 @default.
- W2068933036 cites W1967286022 @default.
- W2068933036 cites W1970436192 @default.
- W2068933036 cites W1971693026 @default.
- W2068933036 cites W1971837077 @default.
- W2068933036 cites W1972702523 @default.
- W2068933036 cites W1977286373 @default.
- W2068933036 cites W1978359670 @default.
- W2068933036 cites W1987689694 @default.
- W2068933036 cites W1987920894 @default.
- W2068933036 cites W1987930488 @default.
- W2068933036 cites W1988051941 @default.
- W2068933036 cites W1988148746 @default.
- W2068933036 cites W1990073288 @default.
- W2068933036 cites W1992106892 @default.
- W2068933036 cites W1992680810 @default.
- W2068933036 cites W1993128964 @default.
- W2068933036 cites W1993919875 @default.
- W2068933036 cites W1996273421 @default.
- W2068933036 cites W1996615534 @default.
- W2068933036 cites W1996703005 @default.
- W2068933036 cites W1998003172 @default.
- W2068933036 cites W1999959802 @default.
- W2068933036 cites W2001671445 @default.
- W2068933036 cites W2004054613 @default.
- W2068933036 cites W2004272510 @default.
- W2068933036 cites W2006152042 @default.
- W2068933036 cites W2009378591 @default.
- W2068933036 cites W2009555529 @default.
- W2068933036 cites W2009671859 @default.
- W2068933036 cites W2009988330 @default.
- W2068933036 cites W2011043511 @default.
- W2068933036 cites W2011883791 @default.
- W2068933036 cites W2015395391 @default.
- W2068933036 cites W2019313527 @default.
- W2068933036 cites W2020215421 @default.
- W2068933036 cites W2023689779 @default.
- W2068933036 cites W2025890159 @default.
- W2068933036 cites W2029945171 @default.
- W2068933036 cites W2035093362 @default.
- W2068933036 cites W2036926413 @default.
- W2068933036 cites W2037480346 @default.
- W2068933036 cites W2038077318 @default.
- W2068933036 cites W2041870613 @default.
- W2068933036 cites W2043382282 @default.
- W2068933036 cites W2047234060 @default.
- W2068933036 cites W2048805127 @default.
- W2068933036 cites W2049311703 @default.
- W2068933036 cites W2052012517 @default.
- W2068933036 cites W2052563206 @default.
- W2068933036 cites W2052583659 @default.
- W2068933036 cites W2057977939 @default.
- W2068933036 cites W2060868676 @default.
- W2068933036 cites W2063342029 @default.
- W2068933036 cites W2068507347 @default.
- W2068933036 cites W2069793759 @default.
- W2068933036 cites W2070318952 @default.
- W2068933036 cites W2074083424 @default.
- W2068933036 cites W2080609540 @default.
- W2068933036 cites W2082227734 @default.
- W2068933036 cites W2087671206 @default.
- W2068933036 cites W2088974319 @default.
- W2068933036 cites W2089114108 @default.
- W2068933036 cites W2090293099 @default.
- W2068933036 cites W2092984818 @default.
- W2068933036 cites W2095440967 @default.
- W2068933036 cites W2100911110 @default.
- W2068933036 cites W2115571323 @default.
- W2068933036 cites W2117538803 @default.
- W2068933036 cites W2117752099 @default.
- W2068933036 cites W2120738370 @default.
- W2068933036 cites W2120995685 @default.
- W2068933036 cites W2121707384 @default.
- W2068933036 cites W2121904561 @default.
- W2068933036 cites W2122105807 @default.
- W2068933036 cites W2122451741 @default.
- W2068933036 cites W2127409621 @default.
- W2068933036 cites W2128796975 @default.
- W2068933036 cites W2132451316 @default.
- W2068933036 cites W2137052325 @default.