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- W2068936088 endingPage "135" @default.
- W2068936088 startingPage "126" @default.
- W2068936088 abstract "MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin. By virtue of its aberrant signaling due to loss of apical-basal polarity in cancer, MUC1 regulates the metabolite flux at multiple levels. Serving as a transcriptional co-activator, MUC1 directly regulates expression of metabolic genes. By regulating receptor tyrosine kinase signaling, MUC1 facilitates production of biosynthetic intermediates required for cell growth. Also, via direct interactions, MUC1 modulates the activity/stability of enzymes and transcription factors that directly regulate metabolic functions. Additionally, by modulation of autophagy, levels of reactive oxygen species, and metabolite flux, MUC1 facilitates cancer cell survival under hypoxic and nutrient-deprived conditions. This article provides a comprehensive review of recent literature on novel metabolic functions of MUC1." @default.
- W2068936088 created "2016-06-24" @default.
- W2068936088 creator A5060280196 @default.
- W2068936088 creator A5067292361 @default.
- W2068936088 date "2014-04-01" @default.
- W2068936088 modified "2023-10-07" @default.
- W2068936088 title "MUC1: A novel metabolic master regulator" @default.
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