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- W2068942685 endingPage "503" @default.
- W2068942685 startingPage "492" @default.
- W2068942685 abstract "RNA interference is a naturally occurring endogenous regulatory process where short double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small interference RNA (siRNA) represents a promising therapeutic strategy. Clinical evaluations of siRNA therapeutics in locoregional treatment settings began in 2004. Systemic siRNA therapy is hampered by the barriers for siRNA to reach their intended targets in the cytoplasm and to exert their gene silencing activity. The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and lipid-based siRNA carriers; and (c) the current status of the clinical trials of siRNA therapeutics." @default.
- W2068942685 created "2016-06-24" @default.
- W2068942685 creator A5075877965 @default.
- W2068942685 creator A5077645346 @default.
- W2068942685 creator A5080936191 @default.
- W2068942685 creator A5085031128 @default.
- W2068942685 date "2010-06-11" @default.
- W2068942685 modified "2023-10-14" @default.
- W2068942685 title "Delivery of siRNA Therapeutics: Barriers and Carriers" @default.
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