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• W2068954505 abstract "The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor." @default.
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• W2068954505 date "1998-03-01" @default.
• W2068954505 modified "2023-10-18" @default.
• W2068954505 title "μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality" @default.
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• W2068954505 doi "https://doi.org/10.1016/s0169-328x(97)00353-7" @default.
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