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• W2068956255 abstract "The purpose of this study was to evaluate the effects of longitudinal drift in scanner hardware, inter-scanner variability (bias) and scanner upgrade on asymmetries of diffusion properties using longitudinal data obtained on two scanners of the exact same model at one institution. A total of 224 normal subjects (63 females and 161 males) were included in this study. Each subject was scanned twice, at an interval of about 1 year (mean interval = 1.0 ± 0.11 years, range = 0.6–1.3 years), using two 3.0-T scanners of the exact same model. Both scanners were simultaneously upgraded during the study period (159 subjects underwent a follow-up scan before upgrade, and the remaining 65 subjects underwent a follow-up scan after upgrade). The subjects were divided into 4 groups according to the combination of scanners used. With the use of tract-based spatial statistics (TBSS), we investigated the effects of scanner drift and inter-scanner variability (bias) on asymmetries of fractional anisotropy (FA) and mean diffusivity (MD). We also investigated the effect of scanner upgrade on FA and MD asymmetries. The voxel-wise analyses revealed a number of regions with significant longitudinal changes in FA and MD asymmetries in the groups where baseline and follow-up images were obtained on different scanners. Even with scanners of the exact same model, inter-scanner variability (bias) significantly affected FA and MD asymmetries, which were relatively stable within the same scanner. Scanner upgrade had a small effect on FA and MD asymmetries. The results indicate that the use of multiple scanners increases variability of DTI asymmetry measurements, and can affect the results of cross-sectional and especially longitudinal DTI asymmetry studies." @default.
• W2068956255 created "2016-06-24" @default.
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• W2068956255 date "2011-01-01" @default.
• W2068956255 modified "2023-10-03" @default.
• W2068956255 title "Effect of scanner in asymmetry studies using diffusion tensor imaging" @default.
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• W2068956255 doi "https://doi.org/10.1016/j.neuroimage.2010.09.023" @default.
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