Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068969213> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2068969213 endingPage "2916" @default.
- W2068969213 startingPage "2913" @default.
- W2068969213 abstract "We have developed new hybrid systems consisting of anticancer drugs such as methotrexate (MTX) or 5-fluorouracil (5-FU) and two-dimensional inorganic delivery carrier like layered double hydroxide (LDH). Such an inorganic vector with biocompatible metal ions can be used to overcome toxicity, immunogenecity and poor integration capacity, which are critical problems caused by conventional viral vectors, cationic liposomes and polymers. Moreover, the intercellular mechanism of LDH nanoparticles is primarily related to clathrin-mediated endocytosis, resultihg in effective delivery and eventually enhancing drug efficacy. In this report, the effect of LDH intercalated with 5-Fu (5-Fu-LDH) was evaluated in whole animal by studying pharmacokinetic behavior and tissue distribution. The results showed that 5-Fu-LDH exhibited favorable blood clearance profiles compared to free 5-Fu, such as sustained drug release, prolonged drug half-life, and increased drug accumulation in target tumor tissue. Furthermore, LDH nanoparticles were rapidly excreted from the body and not accumulated in the organs after administration as 5-Fu-LDH. Therefore, the hybrid system can be promising anticancer chemotherapy agent for tumor targeting with biocompatibility." @default.
- W2068969213 created "2016-06-24" @default.
- W2068969213 creator A5011102304 @default.
- W2068969213 creator A5037611086 @default.
- W2068969213 creator A5051314814 @default.
- W2068969213 date "2010-04-01" @default.
- W2068969213 modified "2023-10-16" @default.
- W2068969213 title "Biocompatible Nanoparticles Intercalated with Anticancer Drug for Target Delivery: Pharmacokinetic and Biodistribution Study" @default.
- W2068969213 doi "https://doi.org/10.1166/jnn.2010.1415" @default.
- W2068969213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20355523" @default.
- W2068969213 hasPublicationYear "2010" @default.
- W2068969213 type Work @default.
- W2068969213 sameAs 2068969213 @default.
- W2068969213 citedByCount "78" @default.
- W2068969213 countsByYear W20689692132012 @default.
- W2068969213 countsByYear W20689692132013 @default.
- W2068969213 countsByYear W20689692132014 @default.
- W2068969213 countsByYear W20689692132015 @default.
- W2068969213 countsByYear W20689692132016 @default.
- W2068969213 countsByYear W20689692132017 @default.
- W2068969213 countsByYear W20689692132018 @default.
- W2068969213 countsByYear W20689692132019 @default.
- W2068969213 countsByYear W20689692132020 @default.
- W2068969213 countsByYear W20689692132021 @default.
- W2068969213 countsByYear W20689692132022 @default.
- W2068969213 countsByYear W20689692132023 @default.
- W2068969213 crossrefType "journal-article" @default.
- W2068969213 hasAuthorship W2068969213A5011102304 @default.
- W2068969213 hasAuthorship W2068969213A5037611086 @default.
- W2068969213 hasAuthorship W2068969213A5051314814 @default.
- W2068969213 hasConcept C110121322 @default.
- W2068969213 hasConcept C112705442 @default.
- W2068969213 hasConcept C126511603 @default.
- W2068969213 hasConcept C13245373 @default.
- W2068969213 hasConcept C134306372 @default.
- W2068969213 hasConcept C141071460 @default.
- W2068969213 hasConcept C1491633281 @default.
- W2068969213 hasConcept C171250308 @default.
- W2068969213 hasConcept C185154212 @default.
- W2068969213 hasConcept C185592680 @default.
- W2068969213 hasConcept C191897082 @default.
- W2068969213 hasConcept C192562407 @default.
- W2068969213 hasConcept C202751555 @default.
- W2068969213 hasConcept C2776694085 @default.
- W2068969213 hasConcept C2777230088 @default.
- W2068969213 hasConcept C2777807558 @default.
- W2068969213 hasConcept C2779820397 @default.
- W2068969213 hasConcept C2780035454 @default.
- W2068969213 hasConcept C2781303535 @default.
- W2068969213 hasConcept C28005876 @default.
- W2068969213 hasConcept C33923547 @default.
- W2068969213 hasConcept C55493867 @default.
- W2068969213 hasConcept C71924100 @default.
- W2068969213 hasConcept C98274493 @default.
- W2068969213 hasConceptScore W2068969213C110121322 @default.
- W2068969213 hasConceptScore W2068969213C112705442 @default.
- W2068969213 hasConceptScore W2068969213C126511603 @default.
- W2068969213 hasConceptScore W2068969213C13245373 @default.
- W2068969213 hasConceptScore W2068969213C134306372 @default.
- W2068969213 hasConceptScore W2068969213C141071460 @default.
- W2068969213 hasConceptScore W2068969213C1491633281 @default.
- W2068969213 hasConceptScore W2068969213C171250308 @default.
- W2068969213 hasConceptScore W2068969213C185154212 @default.
- W2068969213 hasConceptScore W2068969213C185592680 @default.
- W2068969213 hasConceptScore W2068969213C191897082 @default.
- W2068969213 hasConceptScore W2068969213C192562407 @default.
- W2068969213 hasConceptScore W2068969213C202751555 @default.
- W2068969213 hasConceptScore W2068969213C2776694085 @default.
- W2068969213 hasConceptScore W2068969213C2777230088 @default.
- W2068969213 hasConceptScore W2068969213C2777807558 @default.
- W2068969213 hasConceptScore W2068969213C2779820397 @default.
- W2068969213 hasConceptScore W2068969213C2780035454 @default.
- W2068969213 hasConceptScore W2068969213C2781303535 @default.
- W2068969213 hasConceptScore W2068969213C28005876 @default.
- W2068969213 hasConceptScore W2068969213C33923547 @default.
- W2068969213 hasConceptScore W2068969213C55493867 @default.
- W2068969213 hasConceptScore W2068969213C71924100 @default.
- W2068969213 hasConceptScore W2068969213C98274493 @default.
- W2068969213 hasIssue "4" @default.
- W2068969213 hasLocation W20689692131 @default.
- W2068969213 hasLocation W20689692132 @default.
- W2068969213 hasOpenAccess W2068969213 @default.
- W2068969213 hasPrimaryLocation W20689692131 @default.
- W2068969213 hasRelatedWork W2002675502 @default.
- W2068969213 hasRelatedWork W2036462195 @default.
- W2068969213 hasRelatedWork W2080630976 @default.
- W2068969213 hasRelatedWork W2115056075 @default.
- W2068969213 hasRelatedWork W2316079134 @default.
- W2068969213 hasRelatedWork W2790856884 @default.
- W2068969213 hasRelatedWork W2991981173 @default.
- W2068969213 hasRelatedWork W3093573816 @default.
- W2068969213 hasRelatedWork W4226035572 @default.
- W2068969213 hasRelatedWork W2186763223 @default.
- W2068969213 hasVolume "10" @default.
- W2068969213 isParatext "false" @default.
- W2068969213 isRetracted "false" @default.
- W2068969213 magId "2068969213" @default.
- W2068969213 workType "article" @default.