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- W2068975284 abstract "Renal clearance of zinc was examined in 6 infants with fetal alcohol syndrome (FAS) to determine if there is a link between prenatal exposure to ethanol and zinc deficiency in the development of fetal dysmorphogenesis. Eight healthy age-matched infants served as controls. There was no significant difference in creatinine clearance, urine flow rate, or fractional water excretion values between the two groups. Plasma concentrations of zinc were significantly lower in FAS patients (62.5±2.8 μg/dL) in comparison to controls (70.3±2.3 μg/dL), (P<.00005). Urinary excretion of zinc in FAS patients averaged 646±125 μg/24 hr; significantly higher than in control subjects (330±184 μg/24 hr), (P<.00005). Fractional excretion of zinc (FEZn was significantly higher in FAS patients (2.8±1.1%) compared to control group (1.4±.07%), (P=.02), but the mean filtered zinc (FZn) was significantly lower in patients than in controls (P=.02). The changes in FEZn for FAS patients varied inversely with urine flow rate (r=-.58, P=.002) and with FZn (r=-.39, P=.0001), but varied directly with fractional water excretion (r=.20, P=.008). Thus: (1) Plasma zinc deficiency is present in infants with FAS; (2) increased fractional clearance of zinc appears to be responsible for decreased plasma zinc concentrations; (3) relative zinc deficiency in FAS patients may be responsible for some of the features associated with the syndrome." @default.
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- W2068975284 date "1985-04-01" @default.
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- W2068975284 title "342 ZINC PEFICIENCY IN INFANTS WITH FETAL ALCOHOL SYNDROME" @default.
- W2068975284 doi "https://doi.org/10.1203/00006450-198504000-00372" @default.
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