FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068978246> ?p ?o ?g. }

• W2068978246 endingPage "517" @default.
• W2068978246 startingPage "507" @default.
• W2068978246 abstract "Purpose Congenital pseudarthrosis of the tibia (CPT) is a rare but serious disorder in children. No single approach has clearly emerged as superior in terms of operative procedure, fixation, optimal time for surgery or adjunctive pharmaceutical intervention. CPT is frequently associated with neurofibromatosis type 1 (NF1), a condition featuring deficient bone anabolism and excessive catabolism. We have therefore combined the use of bone morphogenetic proteins (BMP) with bisphosphonates (BP) as an adjunct to surgical intervention. Methods Between 2002 and 2008 we administered BMP-7 (OP-1) at the time of surgery followed by BP (pamidronate or zoledronic acid) in eight Crawford type IV CPT cases in seven patients (six with a confirmed diagnosis of NF1) with a median age of 7 years (range 2 years 11 months to 12 years) at surgery. Results In six of eight cases, this approach led to primary healing after a mean of 5.5 months (range 4–7 months). One of these cases represented 17 months after primary healing of a proximal CPT with a new further distal fracture that required multiple operations to finally unite at 19 months. The two remaining cases ultimately reached union after multiple operations at 14 and 30 months, respectively, but required recent treatment for refractures. Conclusion Based on these clinical data (primary healing in 6/8 cases) and prior pre-clinical findings, we propose that BP therapy may be helpful in preserving the BMP-induced bone formation by inhibiting the osteoclastic bone loss. Key factors to achieve union in CPT include sufficient fixation, meticulous resection of the dysplastic tissue and the establishment of a net anabolic environment for bone healing. Whether our biological concept of balancing the anabolic and catabolic responses with BMP and BP improves healing rates in the complex treatment of NF1 CPT remains uncertain and warrants larger prospective multicentre trials." @default.
• W2068978246 created "2016-06-24" @default.
• W2068978246 creator A5044374030 @default.
• W2068978246 creator A5053659589 @default.
• W2068978246 creator A5061032539 @default.
• W2068978246 creator A5072928286 @default.
• W2068978246 creator A5083140994 @default.
• W2068978246 creator A5087374760 @default.
• W2068978246 creator A5087865660 @default.
• W2068978246 date "2010-12-01" @default.
• W2068978246 modified "2023-09-27" @default.
• W2068978246 title "Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia" @default.
• W2068978246 cites W110899431 @default.
• W2068978246 cites W149879129 @default.
• W2068978246 cites W1597347139 @default.
• W2068978246 cites W1966389556 @default.
• W2068978246 cites W1968420925 @default.
• W2068978246 cites W1969142291 @default.
• W2068978246 cites W1972122921 @default.
• W2068978246 cites W1993006174 @default.
• W2068978246 cites W2001583313 @default.
• W2068978246 cites W2016662879 @default.
• W2068978246 cites W2019311925 @default.
• W2068978246 cites W2019479526 @default.
• W2068978246 cites W2022094899 @default.
• W2068978246 cites W2022679333 @default.
• W2068978246 cites W2037609465 @default.
• W2068978246 cites W2052325570 @default.
• W2068978246 cites W2060893035 @default.
• W2068978246 cites W2076370157 @default.
• W2068978246 cites W2077709639 @default.
• W2068978246 cites W2085965947 @default.
• W2068978246 cites W2100831373 @default.
• W2068978246 cites W2111017231 @default.
• W2068978246 cites W2134588765 @default.
• W2068978246 cites W2316195533 @default.
• W2068978246 cites W2318227118 @default.
• W2068978246 cites W2323494381 @default.
• W2068978246 cites W2327037323 @default.
• W2068978246 cites W2413448628 @default.
• W2068978246 cites W3000473592 @default.
• W2068978246 cites W4247430999 @default.
• W2068978246 cites W4249075587 @default.
• W2068978246 cites W4249952013 @default.
• W2068978246 cites W4251160442 @default.
• W2068978246 doi "https://doi.org/10.1007/s11832-010-0293-3" @default.
• W2068978246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2981713" @default.
• W2068978246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22132028" @default.
• W2068978246 hasPublicationYear "2010" @default.
• W2068978246 type Work @default.
• W2068978246 sameAs 2068978246 @default.
• W2068978246 citedByCount "47" @default.
• W2068978246 countsByYear W20689782462012 @default.
• W2068978246 countsByYear W20689782462013 @default.
• W2068978246 countsByYear W20689782462014 @default.
• W2068978246 countsByYear W20689782462015 @default.
• W2068978246 countsByYear W20689782462016 @default.
• W2068978246 countsByYear W20689782462017 @default.
• W2068978246 countsByYear W20689782462018 @default.
• W2068978246 countsByYear W20689782462019 @default.
• W2068978246 countsByYear W20689782462020 @default.
• W2068978246 countsByYear W20689782462021 @default.
• W2068978246 countsByYear W20689782462022 @default.
• W2068978246 crossrefType "journal-article" @default.
• W2068978246 hasAuthorship W2068978246A5044374030 @default.
• W2068978246 hasAuthorship W2068978246A5053659589 @default.
• W2068978246 hasAuthorship W2068978246A5061032539 @default.
• W2068978246 hasAuthorship W2068978246A5072928286 @default.
• W2068978246 hasAuthorship W2068978246A5083140994 @default.
• W2068978246 hasAuthorship W2068978246A5087374760 @default.
• W2068978246 hasAuthorship W2068978246A5087865660 @default.
• W2068978246 hasBestOaLocation W20689782462 @default.
• W2068978246 hasConcept C104317684 @default.
• W2068978246 hasConcept C141071460 @default.
• W2068978246 hasConcept C142724271 @default.
• W2068978246 hasConcept C185592680 @default.
• W2068978246 hasConcept C2776326535 @default.
• W2068978246 hasConcept C2777236700 @default.
• W2068978246 hasConcept C2778984943 @default.
• W2068978246 hasConcept C2779561271 @default.
• W2068978246 hasConcept C2779785605 @default.
• W2068978246 hasConcept C31507581 @default.
• W2068978246 hasConcept C55493867 @default.
• W2068978246 hasConcept C71924100 @default.
• W2068978246 hasConcept C8337478 @default.
• W2068978246 hasConceptScore W2068978246C104317684 @default.
• W2068978246 hasConceptScore W2068978246C141071460 @default.
• W2068978246 hasConceptScore W2068978246C142724271 @default.
• W2068978246 hasConceptScore W2068978246C185592680 @default.
• W2068978246 hasConceptScore W2068978246C2776326535 @default.
• W2068978246 hasConceptScore W2068978246C2777236700 @default.
• W2068978246 hasConceptScore W2068978246C2778984943 @default.
• W2068978246 hasConceptScore W2068978246C2779561271 @default.
• W2068978246 hasConceptScore W2068978246C2779785605 @default.
• W2068978246 hasConceptScore W2068978246C31507581 @default.
• W2068978246 hasConceptScore W2068978246C55493867 @default.
• W2068978246 hasConceptScore W2068978246C71924100 @default.
• W2068978246 hasConceptScore W2068978246C8337478 @default.

• next