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- W2068982298 abstract "Two new N 2 S ligands of MPBDA (N-(2-mercapto-propyl)-1,2-benzenediamine) and MEBDA (N-(2-mercapto-ethyl)-1,2-benzenediamine) were synthesized, and their lipophilic complexes of 99m Tc-MPBDA and 99m Tc-MEBDA were prepared in high yield (>92%) by stannous reduction of 99m TcO 4 - . Effects of pH, reaction temperature and time on the formation of 99m Tc complexes were investigated. Potential use of 99m Tc-MPBDA and 99m Tc-MEBDA in cerebral and myocardial imaging were evaluated in mice. High uptakes are demonstrated in both brain and heart, and residence times within heart are long. Two minutes following i.v. Administration, 1.85%ID of 99m Tc-MPBDA and 1.49%ID of 99m Tc-MEBDA appear in brain, and 1.64%ID of 99m Tc-MPBDA and 1.63%ID of 99m Tc-MEBDA are in heart. At 1hr after injection, 1.17%ID and 1.26%ID of 99m Tc-MPBDA remain respectively in brain and heart, and 0.67%ID and 1.18%ID of 99m Tc-MEBDA remain in brain and heart respectively. The activity in blood clears rapidly and the clearance half-life is less than 15 minutes. The properties of 99m Tc-MPBDA make it a potential useful agent for cerebral and myocardial perfusion imaging." @default.
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- W2068982298 date "1999-08-05" @default.
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- W2068982298 title "Synthesis of new N2S ligands, preparation of 99mTc complexes and their preliminary biodistribution in mice" @default.
- W2068982298 doi "https://doi.org/10.1002/(sici)1099-1344(199907)42:7<629::aid-jlcr225>3.0.co;2-z" @default.
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