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• W2068989866 abstract "The interaction of the enantiomers of the non-steroidal anti-inflammatory drug naproxen (NPX) with human serum albumin (HSA) has been investigated using fluorescence and phosphorescence spectroscopy in the steady-state and time-resolved mode. The absorption, fluorescence excitation, and fluorescence emission spectra of (S)-NPX and (R)-NPX differ in shape in the presence of HSA, indicating that these enantiomers experience a different environment when bound. In solutions containing 0.2 M KI, complexation with HSA results in a strongly increased NPX fluorescence intensity and a decreased NPX phosphorescence intensity due to the inhibition of the collisional interaction with the heavy atom iodide. Fluorescence intensity curves obtained upon selective excitation of NPX show 8-fold different slopes for bound and free NPX. No significant difference in the binding constants of (3.8 ± 0.6) × 105 M−1 for (S)-NPX and (3.9 ± 0.6) × 105 M−1 for (R)-NPX was found. Furthermore, the addition of NPX quenches the phosphorescence of the single tryptophan in HSA (Trp-214) based on Dexter energy transfer. The short-range nature of this mechanism explains the upward curvature of the Stern–Volmer plot observed for HSA: At low concentrations NPX binds to HSA at a distance from Trp-214 and no quenching occurs, whereas at high NPX concentrations the phosphorescence intensity decreases due to dynamic quenching by NPX diffusing into site I from the bulk solution. The dynamic quenching observed in the Stern–Volmer plots based on the longest phosphorescence lifetime indicates an overall binding constant to HSA of about 3 × 105 M−1 for both enantiomers." @default.
• W2068989866 created "2016-06-24" @default.
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• W2068989866 date "2013-03-01" @default.
• W2068989866 modified "2023-09-24" @default.
• W2068989866 title "Binding of naproxen enantiomers to human serum albumin studied by fluorescence and room-temperature phosphorescence" @default.
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• W2068989866 doi "https://doi.org/10.1016/j.saa.2012.12.007" @default.
• W2068989866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23295212" @default.
• W2068989866 hasPublicationYear "2013" @default.
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