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• W2068989984 abstract "Follicular dendritic cells (FDCs) are important for the induction of protective T cell-dependent humoral responses, but their contribution to autoimmunity remains elusive. Here, gene-targeted interruption of FDC development was combined with the K/BxN mouse model of arthritis. We found that FDCs were essential for autoantibody production through two distinct but cooperative functions. In a T cell-independent fashion, FDCs loaded with autoantigen-containing immune complexes supported germinal center (GC) B cell development. Additionally, the integrity of FDC networks was required for the recruitment of arthritogenic follicular helper T cells, a process that drove T-B cell interactions and productive GC reactivity. Importantly, pharmacological interference in the maintenance of FDCs ameliorated disease development, suggesting the FDC as a potential target for dampening autoimmunity." @default.
• W2068989984 created "2016-06-24" @default.
• W2068989984 creator A5027516316 @default.
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• W2068989984 date "2009-01-01" @default.
• W2068989984 modified "2023-09-24" @default.
• W2068989984 title "Induction of Autoantibody-Mediated Spontaneous Arthritis Critically Depends on Follicular Dendritic Cells" @default.
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• W2068989984 doi "https://doi.org/10.1016/j.immuni.2008.10.019" @default.
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