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• W2068990960 abstract "BackgroundIntracardiac calcification is commonly seen in the elderly and preferentially affects the aortic and mitral valves in the form of aortic valve calcification (AVC) and mitral annular calcification (MAC). The presence of AVC or MAC has been shown to be related to atherosclerotic risk factors including age. To gain insight into the pathogenesis of intracardiac calcification, we examined the relationship of AVC and MAC with biomarkers of thrombosis and/or inflammation in patients with mild to moderate aortic stenosis and no hypercholesterolemia.MethodsThe ASTRONOMER study was a double-blind, placebo-controlled, multi-centre trial to assess the effect of lipid lowering on the progression of mild to moderate aortic stenosis. Excluded are patients with any indication for lipid lowering treatment such as diabetes mellitus and known coronary disease. Comprehensive biomechanical and echocardiographic measurements were obtained. In addition to a complete lipid profile, biomarkers of inflammation and/or thrombosis were obtained and included C-reactive protein (CRP), interleukin 6 (IL6), inter-cellular adhesion moledule 1 (ICAM1), e selectin, fibrinogen (FBN), homocysteine (HCY) and insulin (IN).Results272 patients were recruited and followed for a median of 3.5 years. There were 167 men and 105 women, with a mean age of 58 ± 14 years. The peak and mean aortic stenosis gradients were 41 ± 11 and 23 ± 8 mmHg. Bicuspid valve was diagnosed in 133 patients (49%). AVC (moderate or severe) was present in 177 patients, MAC present in 62 patients, and both in 49 patients. Both AVC and MAC were associated with age. AVC was more common in men, whereas MAC tended to be more prevalent in women. Logistic regression models were fit to assess the relationship between individual biomarkers and AVC or MAC. IL6 was excluded from subsequent analyses due to weak sensitivity of the test. The odds ratio and 95% confidence limits are presented in the table.Tabled 1ConclusionFBN, HCY and IN are independent predictors of MAC, but none of the biomarkers were associated with AVC, suggesting that MAC and AVC have different pathogenetic mechanisms. BackgroundIntracardiac calcification is commonly seen in the elderly and preferentially affects the aortic and mitral valves in the form of aortic valve calcification (AVC) and mitral annular calcification (MAC). The presence of AVC or MAC has been shown to be related to atherosclerotic risk factors including age. To gain insight into the pathogenesis of intracardiac calcification, we examined the relationship of AVC and MAC with biomarkers of thrombosis and/or inflammation in patients with mild to moderate aortic stenosis and no hypercholesterolemia. Intracardiac calcification is commonly seen in the elderly and preferentially affects the aortic and mitral valves in the form of aortic valve calcification (AVC) and mitral annular calcification (MAC). The presence of AVC or MAC has been shown to be related to atherosclerotic risk factors including age. To gain insight into the pathogenesis of intracardiac calcification, we examined the relationship of AVC and MAC with biomarkers of thrombosis and/or inflammation in patients with mild to moderate aortic stenosis and no hypercholesterolemia. MethodsThe ASTRONOMER study was a double-blind, placebo-controlled, multi-centre trial to assess the effect of lipid lowering on the progression of mild to moderate aortic stenosis. Excluded are patients with any indication for lipid lowering treatment such as diabetes mellitus and known coronary disease. Comprehensive biomechanical and echocardiographic measurements were obtained. In addition to a complete lipid profile, biomarkers of inflammation and/or thrombosis were obtained and included C-reactive protein (CRP), interleukin 6 (IL6), inter-cellular adhesion moledule 1 (ICAM1), e selectin, fibrinogen (FBN), homocysteine (HCY) and insulin (IN). The ASTRONOMER study was a double-blind, placebo-controlled, multi-centre trial to assess the effect of lipid lowering on the progression of mild to moderate aortic stenosis. Excluded are patients with any indication for lipid lowering treatment such as diabetes mellitus and known coronary disease. Comprehensive biomechanical and echocardiographic measurements were obtained. In addition to a complete lipid profile, biomarkers of inflammation and/or thrombosis were obtained and included C-reactive protein (CRP), interleukin 6 (IL6), inter-cellular adhesion moledule 1 (ICAM1), e selectin, fibrinogen (FBN), homocysteine (HCY) and insulin (IN). Results272 patients were recruited and followed for a median of 3.5 years. There were 167 men and 105 women, with a mean age of 58 ± 14 years. The peak and mean aortic stenosis gradients were 41 ± 11 and 23 ± 8 mmHg. Bicuspid valve was diagnosed in 133 patients (49%). AVC (moderate or severe) was present in 177 patients, MAC present in 62 patients, and both in 49 patients. Both AVC and MAC were associated with age. AVC was more common in men, whereas MAC tended to be more prevalent in women. Logistic regression models were fit to assess the relationship between individual biomarkers and AVC or MAC. IL6 was excluded from subsequent analyses due to weak sensitivity of the test. The odds ratio and 95% confidence limits are presented in the table.Tabled 1 272 patients were recruited and followed for a median of 3.5 years. There were 167 men and 105 women, with a mean age of 58 ± 14 years. The peak and mean aortic stenosis gradients were 41 ± 11 and 23 ± 8 mmHg. Bicuspid valve was diagnosed in 133 patients (49%). AVC (moderate or severe) was present in 177 patients, MAC present in 62 patients, and both in 49 patients. Both AVC and MAC were associated with age. AVC was more common in men, whereas MAC tended to be more prevalent in women. Logistic regression models were fit to assess the relationship between individual biomarkers and AVC or MAC. IL6 was excluded from subsequent analyses due to weak sensitivity of the test. The odds ratio and 95% confidence limits are presented in the table. ConclusionFBN, HCY and IN are independent predictors of MAC, but none of the biomarkers were associated with AVC, suggesting that MAC and AVC have different pathogenetic mechanisms. FBN, HCY and IN are independent predictors of MAC, but none of the biomarkers were associated with AVC, suggesting that MAC and AVC have different pathogenetic mechanisms." @default.
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• W2068990960 title "120 Relationship between biomarkers and intracardiac calcification in patients with mild to moderate aortic stenosis" @default.
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