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• W2068991840 startingPage "58" @default.
• W2068991840 abstract "To evaluate pregnancy safety of hydroxychloroquine (HCQ) for rheumatologic diseases.Prospective comparative observational study done at the Israeli teratology information service between 1998 and 2006.114 HCQ-exposed pregnancies (98.2% in the first trimester, T1) were followed-up and compared with 455 pregnancies of women counseled for non-teratogenic exposure. The difference in the rate of congenital anomalies was not statistically significant [7/97 (7.2%) vs. 15/440 (3.4%), p=0.094]. The analysis was repeated among those exposed in T1 excluding genetic or cytogenetic anomalies or congenital infections [5/95 (5.3%) vs. 14/440 (3.2%), p=0.355]. There were no cases of neonatal lupus erythematosus. The gestational age at delivery was earlier, rate of preterm delivery higher, and birth weight lower, in the HCQ group.The present study suggests that HCQ treatment in pregnancy is not a major human teratogen. The earlier gestational age and lower birth weight might be associated with maternal disease." @default.
• W2068991840 created "2016-06-24" @default.
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• W2068991840 date "2013-08-01" @default.
• W2068991840 modified "2023-10-16" @default.
• W2068991840 title "Pregnancy outcome following in utero exposure to hydroxychloroquine: A prospective comparative observational study" @default.
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• W2068991840 doi "https://doi.org/10.1016/j.reprotox.2013.04.005" @default.
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