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• W2068992197 abstract "The potential influence of GABAergic input to cholinergic basalis neurons was studied in guinea-pig basal forebrain slices. GABA and its agonists were applied to electrophysiologically-identified cholinergic neurons, of which some were labelled with biocytin and confirmed to be choline acetyltransferase-immunoreactive. Immunohistochemistry for glutamate decarboxylase was also performed in some slices and revealed GABAergic varicosities in the vicinity of the biocytin-filled soma and dendrites of electrophysiologically-identified cholinergic cells. From rest (average −63 mV), the cholinergic cells were depolarized by GABA. The depolarization was associated with a decrease in membrane resistance and diminution in firing. The effect was mimicked by muscimol, the specific agonist for GABAA receptors, and not by baclofen, the specific agonist for GABAB receptors, which had no discernible effect. The GABA- and muscimol-evoked depolarization and decrease in resistance were found to be postsynaptic since they persisted in the presence of solutions containing either high Mg2+/low Ca2+ or tetrodotoxin. They were confirmed as being mediated by a GABAA receptor, since they were antagonized by bicuculline. The reversal potential for the muscimol effect was estimated to be ∼−45 mV, which was −15 mV above the resting membrane potential. Finally, in some cholinergic cells, spontaneous subthreshold depolarizing synaptic potentials (average 5 mV in amplitude), which were rarely associated with action potentials, were recorded and found to persist in the presence of glutamate receptor antagonists but to be eliminated by bicuculline. These results suggest that GABAergic input may be depolarizing, yet predominantly inhibitory to cholinergic basalis neurons." @default.
• W2068992197 created "2016-06-24" @default.
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• W2068992197 date "1998-06-01" @default.
• W2068992197 modified "2023-09-27" @default.
• W2068992197 title "GABAergic input to cholinergic nucleus basalis neurons" @default.
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• W2068992197 doi "https://doi.org/10.1016/s0306-4522(98)00094-3" @default.
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• W2068992197 hasPublicationYear "1998" @default.
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