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• W2068992372 startingPage "258" @default.
• W2068992372 abstract "It is known that infection with Sindbis virus (SNV) induces apoptosis, which is inhibited by two pro-survival members of the Bcl-2 family, Bcl-2 and Bcl-xL. However, the mechanism of involvement of the other members of the Bcl-2 family in SNV-induced apoptosis remains unclear. In this study we report that Bad protein, one of the pro-apoptotic Bcl-2 family members, mediates apoptosis in the mammalian cells infected with SNV. Expression of Bad was shown to promote SNV-induced apoptosis in human embryonic kidney 293T and baby hamster kidney cells. SNV infection also induced translocation of endogenous Bad into mitochondria and heterodimerization of Bad with Bcl-xL. On the other hand, the structurally most similar pro-survival members, Bcl-2, Bcl-xL, and Bcl-w, suppressed SNV-induced apoptosis in the absence of Bad, whereas Mcl-1 and A1 did not. Bcl-w could inhibit SNV-induced apoptosis in the presence of Bad, but Bcl-xL could not. Bad could be coimmunoprecipitated with Bcl-xL or Bcl-2, but not with Bcl-w. Two viral Bcl-2 homologs, E1B19K and BHRF1, also suppressed SNV-induced apoptosis irrespective of the presence of Bad and no physical association with Bad was observed. These results suggest that direct interaction of Bad with pro-survival members of the Bcl-2 family contributes to the progress of SNV-induced apoptosis and that nonbinding members restrain SNV-induced apoptosis irrespective of Bad expression." @default.
• W2068992372 created "2016-06-24" @default.
• W2068992372 creator A5038192407 @default.
• W2068992372 creator A5067069537 @default.
• W2068992372 creator A5087837717 @default.
• W2068992372 date "2002-01-01" @default.
• W2068992372 modified "2023-10-17" @default.
• W2068992372 title "Induction of Bad-Mediated Apoptosis by Sindbis Virus Infection: Involvement of Pro-survival Members of the Bcl-2 Family" @default.
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• W2068992372 doi "https://doi.org/10.1006/viro.2001.1206" @default.
• W2068992372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11878929" @default.
• W2068992372 hasPublicationYear "2002" @default.
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