Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068992818> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2068992818 endingPage "565" @default.
- W2068992818 startingPage "555" @default.
- W2068992818 abstract "The effects of the anti-curare agent 4-aminopyridine on the cardiovascular systems of cats and greyhounds under barbiturate-chloralose anaesthesia have been studied. In both species, 4-amino-pyridine produced a transient atropine-sensitive decrease in arterial pressure followed by a prolonged adrenergically-mediated increase. In the cat, the cardiac responses to vagal stimulation and nictitating membrane responses to sympathetic stimulation were augmented after injection of 4-aminopyridine, and the evidence indicated that these effects were the results of increased release of neurotransmitters. In the greyhound, 4-aminopyridine produced increases in the left ventricular systolic pressure and dP/dt max, right atrial pressure, stroke volume, myocardial blood flow, myocardial oxygen consumption, external cardiac work, arterial oxygen content and blood haemoglobin. These effects were attributable to facilitation of sympathetic transmission to the blood vessels, heart and spleen. Heart rate was not much affected because facilitation of vagal transmission to the S-A node counteracted the increased sympathetic effect. In the greyhound, 4-aminopyridine also produced temporary cardiac arrhythmia which was only partly attributable to facilitated sympathetic transmission. In addition there was evidence of a central stimulant action of 4-aminopyridine and of a stimulant action on visceral activity. It is concluded that, while 4-aminopyridine may be useful in certain relatively rare conditions of neuromuscular transmission failure, its actions are too widespread for routine use as an antagonist to non-depolarizing neuromuscular blocking drugs." @default.
- W2068992818 created "2016-06-24" @default.
- W2068992818 creator A5001420246 @default.
- W2068992818 creator A5002764758 @default.
- W2068992818 creator A5012169787 @default.
- W2068992818 creator A5075106875 @default.
- W2068992818 date "1981-06-01" @default.
- W2068992818 modified "2023-09-29" @default.
- W2068992818 title "ACTIONS OF 4-AMINOPYRIDINE ON THE CARDIOVASCULAR SYSTEMS OF ANAESTHETIZED CATS AND DOGS" @default.
- W2068992818 doi "https://doi.org/10.1093/bja/53.6.555" @default.
- W2068992818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7248118" @default.
- W2068992818 hasPublicationYear "1981" @default.
- W2068992818 type Work @default.
- W2068992818 sameAs 2068992818 @default.
- W2068992818 citedByCount "24" @default.
- W2068992818 crossrefType "journal-article" @default.
- W2068992818 hasAuthorship W2068992818A5001420246 @default.
- W2068992818 hasAuthorship W2068992818A5002764758 @default.
- W2068992818 hasAuthorship W2068992818A5012169787 @default.
- W2068992818 hasAuthorship W2068992818A5075106875 @default.
- W2068992818 hasBestOaLocation W20689928181 @default.
- W2068992818 hasConcept C126322002 @default.
- W2068992818 hasConcept C164705383 @default.
- W2068992818 hasConcept C24998067 @default.
- W2068992818 hasConcept C2776725644 @default.
- W2068992818 hasConcept C2777953023 @default.
- W2068992818 hasConcept C2779904517 @default.
- W2068992818 hasConcept C2780557958 @default.
- W2068992818 hasConcept C2780922449 @default.
- W2068992818 hasConcept C42219234 @default.
- W2068992818 hasConcept C71924100 @default.
- W2068992818 hasConcept C83743174 @default.
- W2068992818 hasConcept C84393581 @default.
- W2068992818 hasConceptScore W2068992818C126322002 @default.
- W2068992818 hasConceptScore W2068992818C164705383 @default.
- W2068992818 hasConceptScore W2068992818C24998067 @default.
- W2068992818 hasConceptScore W2068992818C2776725644 @default.
- W2068992818 hasConceptScore W2068992818C2777953023 @default.
- W2068992818 hasConceptScore W2068992818C2779904517 @default.
- W2068992818 hasConceptScore W2068992818C2780557958 @default.
- W2068992818 hasConceptScore W2068992818C2780922449 @default.
- W2068992818 hasConceptScore W2068992818C42219234 @default.
- W2068992818 hasConceptScore W2068992818C71924100 @default.
- W2068992818 hasConceptScore W2068992818C83743174 @default.
- W2068992818 hasConceptScore W2068992818C84393581 @default.
- W2068992818 hasIssue "6" @default.
- W2068992818 hasLocation W20689928181 @default.
- W2068992818 hasLocation W20689928182 @default.
- W2068992818 hasOpenAccess W2068992818 @default.
- W2068992818 hasPrimaryLocation W20689928181 @default.
- W2068992818 hasRelatedWork W1978990055 @default.
- W2068992818 hasRelatedWork W1982530646 @default.
- W2068992818 hasRelatedWork W1992209844 @default.
- W2068992818 hasRelatedWork W2035559684 @default.
- W2068992818 hasRelatedWork W2078555105 @default.
- W2068992818 hasRelatedWork W2081062735 @default.
- W2068992818 hasRelatedWork W2470598955 @default.
- W2068992818 hasRelatedWork W3032375556 @default.
- W2068992818 hasRelatedWork W4224325240 @default.
- W2068992818 hasRelatedWork W4297260011 @default.
- W2068992818 hasVolume "53" @default.
- W2068992818 isParatext "false" @default.
- W2068992818 isRetracted "false" @default.
- W2068992818 magId "2068992818" @default.
- W2068992818 workType "article" @default.