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• W2068994457 abstract "Histologic preparations of lungs from 1-, 5-, 10-, 18-, and 25-day-old postnatal and adult rats were examined immunohistochemically with antibodies specific against chondroitin sulfate (CS), basement membrane chondroitin sulfate proteoglycan (BM-CSPG), heparan sulfate proteoglycan (HSPG), entactin, and laminin. A monoclonal antibody specific for the glycosaminoglycan portion (CS) of CSPG and a monoclonal antibody against the core protein of CSPG were used in an immunoperoxidase sequence to stain extracellular matrix (ECM) components of pulmonary basement membranes (BMs). Anti-CS stained airway BM strongly and alveolar BM weakly in the adult rat lung, as well as in vascular and airway adventitia. In developing lungs, immunoreactivity was strong in all ECM sites, including BM, at day 1 postnatal, and progressively diminished thereafter except in vascular and airway adventitia. Anti-CSPG stained alveolar, airway, and vascular BMs, in addition to smooth muscle external laminae (EL), in the adult and developing rat. Immunostaining for CSPG required hyaluronidase digestion, whereas CS staining was lost with the same treatment. A polyclonal antibody to the core protein of HSPG was found to be similarly distributed to CSPG by immunoperoxidase staining in adult and developing rat lungs, with the notable exception that little immunoreactivity for HSPG was found in smooth muscle EL. Commercially obtained polyclonal antibodies to entactin and laminin gave immunostaining comparable to that seen with CSPG, except that entactin showed particular affinity for EL. These results offer a more detailed perspective on previous survey observations of CSPG, HSPG, and entactin in the rat lung, and describe the immunoreactivity of CS for the first time. These BM components, described for the first time in postnatal pulmonary development, were expressed in a regionally specific and time-dependent fashion. All these BM components would be expected to be important determinants of epithelial attachment, proliferation, and differentiation during growth, maturation, and repair following injury." @default.
• W2068994457 created "2016-06-24" @default.
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• W2068994457 date "1993-03-01" @default.
• W2068994457 modified "2023-09-27" @default.
• W2068994457 title "Immunohistochemical Localization of Chondroitin Sulfate, Chondroitin Sulfate Proteoglycan, Heparan Sulfate Proteoglycan, Entactin, and Laminin in Basement Membranes of Postnatal Developing and Adult Rat Lungs" @default.
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• W2068994457 doi "https://doi.org/10.1165/ajrcmb/8.3.245" @default.
• W2068994457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8448015" @default.
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