Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068995113> ?p ?o ?g. }
- W2068995113 endingPage "819" @default.
- W2068995113 startingPage "804" @default.
- W2068995113 abstract "A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy were identified within the neuronal PAS domain protein 3 gene (NPAS3), close to a translocation breakpoint site previously observed in a family with schizophrenia. Five other loci were identified that include the XK, Kell blood group complex subunit-related family, member 4 gene (XKR4), the tenascin-R gene (TNR), the glutamate receptor, inotropic, AMPA 4 gene (GRIA4), the glial cell line-derived neurotrophic factor receptor-alpha2 gene (GFRA2), and the NUDT9P1 pseudogene located in the chromosomal region of the serotonin receptor 7 gene (HTR7). The study of these polymorphisms and genes may lead to a better understanding of the etiology of schizophrenia and of its treatment. These results provide new insight into response to iloperidone, developed with the ultimate goal of directing therapy to patients with the highest benefit-to-risk ratio." @default.
- W2068995113 created "2016-06-24" @default.
- W2068995113 creator A5004768216 @default.
- W2068995113 creator A5013202358 @default.
- W2068995113 creator A5031674961 @default.
- W2068995113 creator A5037934539 @default.
- W2068995113 creator A5041851431 @default.
- W2068995113 creator A5042489839 @default.
- W2068995113 creator A5050928586 @default.
- W2068995113 creator A5055185763 @default.
- W2068995113 creator A5081139995 @default.
- W2068995113 creator A5083427876 @default.
- W2068995113 date "2008-06-03" @default.
- W2068995113 modified "2023-10-15" @default.
- W2068995113 title "Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study" @default.
- W2068995113 cites W1517566746 @default.
- W2068995113 cites W1545695267 @default.
- W2068995113 cites W1970385549 @default.
- W2068995113 cites W1970486486 @default.
- W2068995113 cites W1973852234 @default.
- W2068995113 cites W1974736226 @default.
- W2068995113 cites W1977396922 @default.
- W2068995113 cites W1979487609 @default.
- W2068995113 cites W1980615545 @default.
- W2068995113 cites W1995039946 @default.
- W2068995113 cites W1996107671 @default.
- W2068995113 cites W2003356174 @default.
- W2068995113 cites W2004881650 @default.
- W2068995113 cites W2007701539 @default.
- W2068995113 cites W2010790855 @default.
- W2068995113 cites W2012183345 @default.
- W2068995113 cites W2020237866 @default.
- W2068995113 cites W2022686886 @default.
- W2068995113 cites W2030088966 @default.
- W2068995113 cites W2030819901 @default.
- W2068995113 cites W2033470111 @default.
- W2068995113 cites W2042833856 @default.
- W2068995113 cites W2043246947 @default.
- W2068995113 cites W2046630524 @default.
- W2068995113 cites W2049320347 @default.
- W2068995113 cites W2050711988 @default.
- W2068995113 cites W2051905619 @default.
- W2068995113 cites W2052677604 @default.
- W2068995113 cites W2056051244 @default.
- W2068995113 cites W2058954695 @default.
- W2068995113 cites W2068564214 @default.
- W2068995113 cites W2071844775 @default.
- W2068995113 cites W2073155558 @default.
- W2068995113 cites W2086583079 @default.
- W2068995113 cites W2086622613 @default.
- W2068995113 cites W2094769668 @default.
- W2068995113 cites W2097199945 @default.
- W2068995113 cites W2097355672 @default.
- W2068995113 cites W2098126593 @default.
- W2068995113 cites W2101510083 @default.
- W2068995113 cites W2116251070 @default.
- W2068995113 cites W2119711772 @default.
- W2068995113 cites W2123774216 @default.
- W2068995113 cites W2124718950 @default.
- W2068995113 cites W2131280315 @default.
- W2068995113 cites W2135915809 @default.
- W2068995113 cites W2137788868 @default.
- W2068995113 cites W2145731152 @default.
- W2068995113 cites W2158490907 @default.
- W2068995113 cites W2159155203 @default.
- W2068995113 cites W3049811 @default.
- W2068995113 cites W4231716456 @default.
- W2068995113 doi "https://doi.org/10.1038/mp.2008.56" @default.
- W2068995113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18521090" @default.
- W2068995113 hasPublicationYear "2008" @default.
- W2068995113 type Work @default.
- W2068995113 sameAs 2068995113 @default.
- W2068995113 citedByCount "134" @default.
- W2068995113 countsByYear W20689951132012 @default.
- W2068995113 countsByYear W20689951132013 @default.
- W2068995113 countsByYear W20689951132014 @default.
- W2068995113 countsByYear W20689951132015 @default.
- W2068995113 countsByYear W20689951132016 @default.
- W2068995113 countsByYear W20689951132017 @default.
- W2068995113 countsByYear W20689951132018 @default.
- W2068995113 countsByYear W20689951132019 @default.
- W2068995113 countsByYear W20689951132020 @default.
- W2068995113 countsByYear W20689951132021 @default.
- W2068995113 countsByYear W20689951132022 @default.
- W2068995113 countsByYear W20689951132023 @default.
- W2068995113 crossrefType "journal-article" @default.
- W2068995113 hasAuthorship W2068995113A5004768216 @default.
- W2068995113 hasAuthorship W2068995113A5013202358 @default.
- W2068995113 hasAuthorship W2068995113A5031674961 @default.
- W2068995113 hasAuthorship W2068995113A5037934539 @default.
- W2068995113 hasAuthorship W2068995113A5041851431 @default.
- W2068995113 hasAuthorship W2068995113A5042489839 @default.
- W2068995113 hasAuthorship W2068995113A5050928586 @default.
- W2068995113 hasAuthorship W2068995113A5055185763 @default.
- W2068995113 hasAuthorship W2068995113A5081139995 @default.
- W2068995113 hasAuthorship W2068995113A5083427876 @default.
- W2068995113 hasBestOaLocation W20689951131 @default.
- W2068995113 hasConcept C104317684 @default.