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• W2068997361 abstract "The term peritonitis indicates an inflammatory process involving the peritoneum that is most frequently infectious in nature. Primary or spontaneous bacterial peritonitis (SBP) typically occurs when a bacterial infection spreads to the peritoneum across the gut wall or mesenteric lymphatics or, less frequently, from hematogenous transmission in combination with impaired immune system and in absence of an identified intra-abdominal source of infection or malignancy. The clinical presentation of SBP is variable. The condition may manifest as a relatively insidious colonization, without signs and symptoms, or may suddenly occur as a septic syndrome. Laboratory diagnostics play a pivotal role for timely and appropriate management of patients with bacterial peritonitis. It is now clearly established that polymorphonuclear leukocyte (PMN) in peritoneal fluid is the mainstay for the diagnosis, whereas the role of additional biochemical tests is rather controversial. Recent evidence also suggests that automatic cell counting in peritoneal fluid may be a reliable approach for early screening of patients. According to available clinical and laboratory data, we have developed a tentative algorithm for efficient diagnosis of SBP, which is based on a reasonable integration between optimization of human/economical resources and gradually increasing use of invasive and expensive testing. The proposed strategy entails, in sequential steps, serum procalcitonin testing, automated cell count in peritoneal fluid, manual cell count in peritoneal fluid, peritoneal fluid culture and bacterial DNA testing in peritoneal fluid." @default.
• W2068997361 created "2016-06-24" @default.
• W2068997361 creator A5019108260 @default.
• W2068997361 creator A5049648916 @default.
• W2068997361 creator A5073522064 @default.
• W2068997361 creator A5089475984 @default.
• W2068997361 date "2014-03-01" @default.
• W2068997361 modified "2023-09-25" @default.
• W2068997361 title "Laboratory diagnostics of spontaneous bacterial peritonitis" @default.
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• W2068997361 doi "https://doi.org/10.1016/j.cca.2014.01.023" @default.
• W2068997361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24508989" @default.
• W2068997361 hasPublicationYear "2014" @default.
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