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• W2068997614 abstract "Endothelial cells are recognized as primary targets of vascular damage in septicemia both as a result of direct action of bacterial toxins or from indirect actions mediated by other cell types and their products (including cytokines, enzymes, and oxygen radicals). We have now demonstrated that endothelial cells phagocytize bacteria 1 Ryan US Phagocytic properties of endothelial cells. in: Ryan US Endothelial cells (vol 3). CRC Press, Boca Raton, Fla1988: 33-49 Google Scholar and are capable of bactericidal activity involving generation of oxygen free radicals. 2 Ryan US Vann JM Endothelial cells: a source and target of oxidant damage. in: Simic MG Taylor KA Ward AF Oxygen radicals in biology and medicine. Plenum Publishing, New York1987: 963-968 Google Scholar We have examined mechanisms involved in recognition of bacterial strains, the mechanisms involved in signal transduction leading to the respiratory burst, and the molecular mechanisms controlling the release of reactive oxygen species. 3 Ryan US, Schultz DR, Goodwin JD, Vann JM, Selvaraj MP, Hart MA. Role of Clq in phagocytosis of S. minnesota by pulmonary endothelial cells, (in press) Google Scholar Endothelial cells distinguish between the mutant (Re), which is taken up in large numbers, and the wild (S) form, which is not phagocytized, of Salmonella minnesota. The Re mutant binds Clq (subunit of the first component of complement), while the S type does not. When bacteria or endothelial cells were incubated with C1q-enriched or C1q-depleted sera, data show that Clq mediates binding to the Re mutant by the globular head region of the molecule and to receptors on the endothelial surface via the collagen-like tail region. Further, the release of superoxide anion in response to phagocytosis appears to involve Clq as a stimulus. 3 Ryan US, Schultz DR, Goodwin JD, Vann JM, Selvaraj MP, Hart MA. Role of Clq in phagocytosis of S. minnesota by pulmonary endothelial cells, (in press) Google Scholar Thus, Clq acts as an opsonin." @default.
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• W2068997614 date "1989-03-01" @default.
• W2068997614 modified "2023-10-18" @default.
• W2068997614 title "Endothelial Cells and Bacterial Infection" @default.
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• W2068997614 doi "https://doi.org/10.1378/chest.95.3_supplement.174s" @default.
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