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• W2069013650 startingPage "434" @default.
• W2069013650 abstract "Mitochondrial calcium uniporter (MCU) is a conserved Ca(2+) transporter at mitochondrial in eukaryotic cells. However, the role of MCU protein in oxidative stress-induced cell death remains unclear. Here, we showed that ectopically expressed MCU is mitochondrial localized in both HeLa and primary cerebellar granule neurons (CGNs). Knockdown of endogenous MCU decreases mitochondrial Ca(2+) uptake following histamine stimulation and attenuates cell death induced by oxidative stress in both HeLa cells and CGNs. We also found MCU interacts with VDAC1 and mediates VDAC1 overexpression-induced cell death in CGNs. This finding demonstrates that MCU-VDAC1 complex regulates mitochondrial Ca(2+) uptake and oxidative stress-induced apoptosis, which might represent therapeutic targets for oxidative stress related diseases." @default.
• W2069013650 created "2016-06-24" @default.
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• W2069013650 date "2015-03-11" @default.
• W2069013650 modified "2023-10-18" @default.
• W2069013650 title "Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death" @default.
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• W2069013650 doi "https://doi.org/10.1007/s13238-015-0144-6" @default.
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