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- W2069014723 abstract "We conducted a trial of long-term ganciclovir prophylaxis for prevention of primary cytomegalovirus (CMV) disease in CMV-seronegative liver transplant recipients with CMV-seropositive donors.Patients received intravenous ganciclovir at a dose of 6 mg/kg once a day from day 1 to day 30 after transplant, and then at a dose of 6 mg/kg once a day, Monday through Friday, until day 100. Forty-seven consecutive patients were evaluated. Due to the primary physician's decision or administrative error, 10 patients received less than 7 weeks of ganciclovir (mean duration, 3 weeks).Four of the 10 (40%) patients who received less than 7 weeks of ganciclovir developed CMV disease (hepatitis). In contrast, none of the 37 patients given 100 days of prophylactic ganciclovir developed CMV disease while receiving ganciclovir. Two patients (5.4%) subsequently developed CMV disease (hepatitis) 21 and 88 days, respectively, after completing their ganciclovir prophylaxis. Reversible neutropenia in three patients (8.1%) was the only side effect associated with long-term ganciclovir. Complications from central intravenous catheters did not occur.These results reaffirm the efficacy and safety of long-term ganciclovir prophylaxis for prevention of primary CMV disease in a large number of high-risk CMV-seronegative liver transplant recipients with CMV-seropositive donors." @default.
- W2069014723 created "2016-06-24" @default.
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- W2069014723 date "1997-12-01" @default.
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- W2069014723 title "LONG-TERM GANCICLOVIR PROPHYLAXIS FOR SUCCESSFUL PREVENTION OF PRIMARY CYTOMEGALOVIRUS (CMV) DISEASE IN CMV-SERONEGATIVE LIVER TRANSPLANT RECIPIENTS WITH CMV-SEROPOSITIVE DONORS1" @default.
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- W2069014723 doi "https://doi.org/10.1097/00007890-199712150-00022" @default.
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