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• W2069030027 abstract "1 The effects of acetylcholine (ACh) on pyramidal neurones acutely dissociated from the rat cerebral cortex were studied in the whole-cell mode, by use of the nystatin-perforated patch recording configuration. 2 ACh induced a net inward current (IACh) accompanied by a membrane conductance decrease at a holding potential (VH) of − 40 mV. IACh increased in a concentration-dependent manner with a half-maximum concentration (EC50) of 8.7 × 10−7 M. 3 IACh mainly resulted from the suppression of the voltage- and time-dependent K+ current (M-current). 4 Muscarine and muscarinic agonists such as McN-A-343, oxotremorine and oxotremorine-M mimicked the ACh response. The potency was in the order of oxotremorine-M > McN-A-343 ≥ muscarine > oxotremorine. 5 Pirenzepine shifted the concentration-response curve for ACh to the right and the corresponding Schild plot yielded a pA2 value of 7.81. Other muscarinic antagonists also reversibly blocked IACh in a concentration-dependent manner. The inhibitory potency was in the order of atropine > 4-DAMP > pirenzepine > AF-DX-116. 6 IACh could be induced normally even after pre-incubation of dissociated neurones in external solution with 200 ng ml−1 pertussis toxin (PTX) for 8 h, whereas the inhibitory effect of ACh on high-voltage-activated Ca2+ channels was completely abolished by the PTX treatment." @default.
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• W2069030027 date "1994-08-01" @default.
• W2069030027 modified "2023-09-23" @default.
• W2069030027 title "Muscarinic acetylcholine response in pyramidal neurones of rat cerebral cortex" @default.
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• W2069030027 doi "https://doi.org/10.1111/j.1476-5381.1994.tb13205.x" @default.
• W2069030027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910245" @default.
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