FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069031035> ?p ?o ?g. }

• W2069031035 endingPage "187" @default.
• W2069031035 startingPage "179" @default.
• W2069031035 abstract "Isolated pancreatic islets from rat and mouse and the insulinoma cell lines, betaHC9 and RINm5F, were investigated to determine the regulation of metallothionein (MT). Dexamethasone (DEX) increased rat and mouse islet and insulinoma cell MT levels in a time- and concentration-dependent manner. Rat islet MT expression was increased with interleukin-1beta (IL-1beta), but not tumor necrosis factor-alpha (TNF). However, MT induction by IL-1beta and TNF was synergistic with DEX in rat islets and insulinoma cells. Mouse islet MT failed to respond to IL-1beta alone, although IL-1beta and TNF were synergistic. IL-1beta and TNF did not synergize with DEX for mouse islet MT induction. Zinc sulfate induced MT in rat islets but not mouse islets. MT messenger RNA levels were significantly increased in rat islets in response to DEX and IL-1beta plus DEX. The inducible nitric oxide synthase inhibitors N(G)-monomethyl-L-arginine and aminoguanidine failed to inhibit IL-1beta induced MT levels in insulinoma cells, and the nitric oxide generating agent sodium nitroprusside failed to significantly affect MT levels. Phorbol dibutyrate increased MT levels in rat islets and betaHC9 cells, but phorbol dibutyrate and IL-1beta effects were not additive. Transgenic MT-null and wild-type mouse islets had similar insulin contents, but basal and glucose-stimulated insulin release from MT-null islets were significantly lower than in wild-type islets. Blood glucose levels in MT-null mice were, however, slightly lower than those in wild-type mice. Thus, MT induction in pancreatic islets and beta-cells is regulated by cytokines and DEX, and protein kinase C activation may play a role. However, regulation of MT induction in mouse and rat islets differs. MT also appears to modulate insulin release from pancreatic islets." @default.
• W2069031035 created "2016-06-24" @default.
• W2069031035 creator A5007612017 @default.
• W2069031035 creator A5018361663 @default.
• W2069031035 creator A5022336678 @default.
• W2069031035 date "2000-07-25" @default.
• W2069031035 modified "2023-10-16" @default.
• W2069031035 title "Metallothionein induction in islets of Langerhans and insulinoma cells" @default.
• W2069031035 cites W1493113918 @default.
• W2069031035 cites W1517806507 @default.
• W2069031035 cites W167158170 @default.
• W2069031035 cites W1969533718 @default.
• W2069031035 cites W1969929211 @default.
• W2069031035 cites W1970929172 @default.
• W2069031035 cites W1972272933 @default.
• W2069031035 cites W1985964535 @default.
• W2069031035 cites W1987567408 @default.
• W2069031035 cites W1988547731 @default.
• W2069031035 cites W1989316780 @default.
• W2069031035 cites W1990131757 @default.
• W2069031035 cites W1994681151 @default.
• W2069031035 cites W1996211746 @default.
• W2069031035 cites W2006924731 @default.
• W2069031035 cites W2008030481 @default.
• W2069031035 cites W2009571109 @default.
• W2069031035 cites W2010290591 @default.
• W2069031035 cites W2031121245 @default.
• W2069031035 cites W2031404007 @default.
• W2069031035 cites W2035047102 @default.
• W2069031035 cites W2038282838 @default.
• W2069031035 cites W2038655329 @default.
• W2069031035 cites W2040566578 @default.
• W2069031035 cites W2045846314 @default.
• W2069031035 cites W2051445650 @default.
• W2069031035 cites W2053862721 @default.
• W2069031035 cites W2059122543 @default.
• W2069031035 cites W2064520594 @default.
• W2069031035 cites W2077824574 @default.
• W2069031035 cites W2093444646 @default.
• W2069031035 cites W2104734659 @default.
• W2069031035 cites W2114920291 @default.
• W2069031035 cites W2116112001 @default.
• W2069031035 cites W2130850891 @default.
• W2069031035 cites W2140318963 @default.
• W2069031035 cites W2143546229 @default.
• W2069031035 cites W2156044622 @default.
• W2069031035 cites W2162367837 @default.
• W2069031035 cites W2168458794 @default.
• W2069031035 cites W2214671441 @default.
• W2069031035 cites W2256595785 @default.
• W2069031035 cites W2284349694 @default.
• W2069031035 cites W2331176038 @default.
• W2069031035 cites W2413914254 @default.
• W2069031035 cites W5401597 @default.
• W2069031035 doi "https://doi.org/10.1016/s0303-7207(00)00247-1" @default.
• W2069031035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10940496" @default.
• W2069031035 hasPublicationYear "2000" @default.
• W2069031035 type Work @default.
• W2069031035 sameAs 2069031035 @default.
• W2069031035 citedByCount "15" @default.
• W2069031035 countsByYear W20690310352013 @default.
• W2069031035 countsByYear W20690310352016 @default.
• W2069031035 countsByYear W20690310352019 @default.
• W2069031035 countsByYear W20690310352021 @default.
• W2069031035 crossrefType "journal-article" @default.
• W2069031035 hasAuthorship W2069031035A5007612017 @default.
• W2069031035 hasAuthorship W2069031035A5018361663 @default.
• W2069031035 hasAuthorship W2069031035A5022336678 @default.
• W2069031035 hasConcept C104317684 @default.
• W2069031035 hasConcept C126322002 @default.
• W2069031035 hasConcept C134018914 @default.
• W2069031035 hasConcept C165220095 @default.
• W2069031035 hasConcept C185592680 @default.
• W2069031035 hasConcept C20719415 @default.
• W2069031035 hasConcept C2777391703 @default.
• W2069031035 hasConcept C2777622882 @default.
• W2069031035 hasConcept C2779306644 @default.
• W2069031035 hasConcept C2779855799 @default.
• W2069031035 hasConcept C2780053029 @default.
• W2069031035 hasConcept C3018667095 @default.
• W2069031035 hasConcept C519581460 @default.
• W2069031035 hasConcept C55493867 @default.
• W2069031035 hasConcept C71924100 @default.
• W2069031035 hasConcept C86803240 @default.
• W2069031035 hasConceptScore W2069031035C104317684 @default.
• W2069031035 hasConceptScore W2069031035C126322002 @default.
• W2069031035 hasConceptScore W2069031035C134018914 @default.
• W2069031035 hasConceptScore W2069031035C165220095 @default.
• W2069031035 hasConceptScore W2069031035C185592680 @default.
• W2069031035 hasConceptScore W2069031035C20719415 @default.
• W2069031035 hasConceptScore W2069031035C2777391703 @default.
• W2069031035 hasConceptScore W2069031035C2777622882 @default.
• W2069031035 hasConceptScore W2069031035C2779306644 @default.
• W2069031035 hasConceptScore W2069031035C2779855799 @default.
• W2069031035 hasConceptScore W2069031035C2780053029 @default.
• W2069031035 hasConceptScore W2069031035C3018667095 @default.
• W2069031035 hasConceptScore W2069031035C519581460 @default.
• W2069031035 hasConceptScore W2069031035C55493867 @default.

• next