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- W2069039287 abstract "Classical NaCa exchange models are based on a symmetric carrier system where Na and Ca competing from the same site, can produce net movement of the other against its electrochemical gradient. We have explored this symmetric assumption by studying the Cao and Nao-dependent Na efflux in dialyzed squid axons in which proper control of both external and internal medium was achieved. The results show: (1) In axons dialyzed without Cai and ATP, Cao-dependent Na efflux cannot be detected even in the absence of Nao. Under these conditions, the level of Na efflux (1 pmol · cm−2 · s−1) is close to that predicted by an electrical ‘leak’. (2) In axons dialyzed with Cai (100 μM) and without ATP, Na efflux measured in 440 mM Nao, is about 4–5 pmol · cm−2 · s−1 and rather insensitive to Cao between 0 and 10 mM. However, in the absence of Nao, a Cao-dependent Na efflux is observed similar in magnitude to that found in the presence of external Na. (3) In the presence of both Cai and ATP, Na efflux into artificial sea-water (440 mM Na, 10 mM Ca) is 18 pmol · cm−2 · s−1. In the absence of Nao the efflux of Na is 7.5 pmol · cm−2 · s−1. In the absence of both Nao and Cao the efflux is close to ‘leak’. With full Nao but no Cao, the Na efflux average 12.6 pmol · cm−2 · s−1. These results indicate a marked asymmetry in the modus operandi of the NaCa exchange system with respect to Cai and ATP. These two substrates are required from the cis side to promote Cao-dependent Na efflux (reversal NaCa exchange)." @default.
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- W2069039287 date "1986-01-01" @default.
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- W2069039287 title "Reverse NaCa exchange requires internal Ca and/or ATP in squid axons" @default.
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- W2069039287 doi "https://doi.org/10.1016/0005-2736(86)90123-9" @default.
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