FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069045904> ?p ?o ?g. }

• W2069045904 abstract "Purpose The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) have been used as first line treatment in advanced Non-Small Cell Lung Cancer (NSCLC) with sensitive EGFR gene mutations. In clinical practice, we found that the rate of EGFR gene mutation in patients with Yin-cold syndrome type in traditional Chinese medicine (TCM) theory was higher than those with Yang-heat type syndrome. The purpose of this study was to identify the relationship between the TCM syndrome type and the EGFR gene status as well as efficacy of EGFR-TKIs in NSCLC patients. Methods From March 2013 to January 2014, we prospectively studied all the patients who are newly diagnosed with NSCLC without prior anticancer therapy, or those with recurrence with an interval of more than 6 moths from last anticancer therapy to the recurrence. The symptoms and signs which can help for the TCM syndrome type diagnosis were recorded. The EGFR gene statuses were also tested. The Yang-heat or Yin-cold syndrome types of TCM were diagnosed respectively by 3 TCM experts of our hospital to decide the TCM syndrome type. The relationship between the EGFR gene status and the TCM syndrome type were analyzed. The patients were followed up until August 2014. Results A total of 73 consecutive patients were enrolled in our study. 32 patients (43.84%) were with the Yin-cold syndrome type according to the TCM theory, while the other 41 patients (56.16%) were with the Yang-heat type. 17 patients (53.13%) in the Yin-cold group, while only 10 patients (24.39%) in the Yang-heat group, were with sensitive EGFR gene mutation (p=0.0120). 1 in the Yin-cold group and 1 in the Yang-heat group were with T790M at the exon 20 of EGFR gene. The EGFR genes were wild type in the other 44 patients. No significant difference was seen in PFS or OS between the TCM syndrome groups for those 22 patients who took EGFR-TKIs. Conclusion Patients with Yin-cold TCM syndrome type have more chance with sensitive EGFR gene mutation. However, no relationship was seen between the efficacy of EGFR-TKIs and TCM syndrome type." @default.
• W2069045904 created "2016-06-24" @default.
• W2069045904 creator A5005413095 @default.
• W2069045904 creator A5023214008 @default.
• W2069045904 creator A5027336778 @default.
• W2069045904 creator A5032396735 @default.
• W2069045904 creator A5034206342 @default.
• W2069045904 creator A5058225779 @default.
• W2069045904 creator A5060911389 @default.
• W2069045904 creator A5066366965 @default.
• W2069045904 creator A5072371916 @default.
• W2069045904 creator A5081752664 @default.
• W2069045904 date "2014-11-01" @default.
• W2069045904 modified "2023-09-30" @default.
• W2069045904 title "Relation between the Yin-cold or Yang-heat syndrome type of TCM and the EGFR gene status in patients with NSCLC" @default.
• W2069045904 cites W1506660188 @default.
• W2069045904 cites W2153477391 @default.
• W2069045904 cites W2164462854 @default.
• W2069045904 cites W2166084034 @default.
• W2069045904 doi "https://doi.org/10.1109/bibm.2014.6999399" @default.
• W2069045904 hasPublicationYear "2014" @default.
• W2069045904 type Work @default.
• W2069045904 sameAs 2069045904 @default.
• W2069045904 citedByCount "0" @default.
• W2069045904 crossrefType "proceedings-article" @default.
• W2069045904 hasAuthorship W2069045904A5005413095 @default.
• W2069045904 hasAuthorship W2069045904A5023214008 @default.
• W2069045904 hasAuthorship W2069045904A5027336778 @default.
• W2069045904 hasAuthorship W2069045904A5032396735 @default.
• W2069045904 hasAuthorship W2069045904A5034206342 @default.
• W2069045904 hasAuthorship W2069045904A5058225779 @default.
• W2069045904 hasAuthorship W2069045904A5060911389 @default.
• W2069045904 hasAuthorship W2069045904A5066366965 @default.
• W2069045904 hasAuthorship W2069045904A5072371916 @default.
• W2069045904 hasAuthorship W2069045904A5081752664 @default.
• W2069045904 hasConcept C121608353 @default.
• W2069045904 hasConcept C126322002 @default.
• W2069045904 hasConcept C142724271 @default.
• W2069045904 hasConcept C143998085 @default.
• W2069045904 hasConcept C188947578 @default.
• W2069045904 hasConcept C204787440 @default.
• W2069045904 hasConcept C2776256026 @default.
• W2069045904 hasConcept C2779177807 @default.
• W2069045904 hasConcept C2779438470 @default.
• W2069045904 hasConcept C71924100 @default.
• W2069045904 hasConcept C81729549 @default.
• W2069045904 hasConceptScore W2069045904C121608353 @default.
• W2069045904 hasConceptScore W2069045904C126322002 @default.
• W2069045904 hasConceptScore W2069045904C142724271 @default.
• W2069045904 hasConceptScore W2069045904C143998085 @default.
• W2069045904 hasConceptScore W2069045904C188947578 @default.
• W2069045904 hasConceptScore W2069045904C204787440 @default.
• W2069045904 hasConceptScore W2069045904C2776256026 @default.
• W2069045904 hasConceptScore W2069045904C2779177807 @default.
• W2069045904 hasConceptScore W2069045904C2779438470 @default.
• W2069045904 hasConceptScore W2069045904C71924100 @default.
• W2069045904 hasConceptScore W2069045904C81729549 @default.
• W2069045904 hasLocation W20690459041 @default.
• W2069045904 hasOpenAccess W2069045904 @default.
• W2069045904 hasPrimaryLocation W20690459041 @default.
• W2069045904 hasRelatedWork W1801337950 @default.
• W2069045904 hasRelatedWork W1930393877 @default.
• W2069045904 hasRelatedWork W1972611878 @default.
• W2069045904 hasRelatedWork W1980223409 @default.
• W2069045904 hasRelatedWork W2042581859 @default.
• W2069045904 hasRelatedWork W2044414123 @default.
• W2069045904 hasRelatedWork W2059891247 @default.
• W2069045904 hasRelatedWork W2121641332 @default.
• W2069045904 hasRelatedWork W2124569973 @default.
• W2069045904 hasRelatedWork W2163513344 @default.
• W2069045904 hasRelatedWork W2163885776 @default.
• W2069045904 hasRelatedWork W2295414473 @default.
• W2069045904 hasRelatedWork W2591703692 @default.
• W2069045904 hasRelatedWork W2752467782 @default.
• W2069045904 hasRelatedWork W2943199436 @default.
• W2069045904 hasRelatedWork W2956741276 @default.
• W2069045904 hasRelatedWork W3024638593 @default.
• W2069045904 hasRelatedWork W3157185389 @default.
• W2069045904 hasRelatedWork W2112901415 @default.
• W2069045904 hasRelatedWork W2621458699 @default.
• W2069045904 isParatext "false" @default.
• W2069045904 isRetracted "false" @default.
• W2069045904 magId "2069045904" @default.
• W2069045904 workType "article" @default.