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- W2069049756 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCThe family of Argonaute genes is essential for stem cell maintenance and RNA interference. Piwi-like genes as a subclass of the Argonaute genes are expressed mainly in the germline. However, these genes may be re-expressed in tumors, and expression of the Piwi-like genes is associated with prognosis in several types of tumors.We analyzed the expression ofPiwi-like mRNAs (Piwi-like 2-4) in125 soft tissue sarcoma (STS) samples by qPCRs. Statistical tests were applied to study the correlation of expression levels with tumor-specific survival forSTS patients.In multivariate Cox's regression analyses, we detected that low Piwi-like2 and Piwi-like 4 mRNA expression were significantly associated with a worse prognosis (RR = 1.87; p = 0.032 andRR = 1.82; p = 0.039). In addition, low expression of both genes was associated with a 2.58-fold increased risk of tumor-related death (p = 0.01).Next we analysed expression of Piwi-like genes gender specific. Piwi-like 4 and combined Piwi-like 2 and 4 mRNA levels correlated significantly with prognosis (RR = 3.53; p= 0.002 and RR = 5.23; p = 0.004) only for female but not for male patients.However, combined low Piwi-like 2 and3 transcript levels were associated with worse survival (RR = 5.90; p = 0.02) for male patients.In this study, we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. A connection between gender and the impact of Piwi-like mRNA expressions on STS patients’ prognosis was shown for the first time.Citation Format: Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschlager, Steffen Goebel, Hans-Jurgen Holzhausen, Sven Wach, Peter Wurl, Helge W. Taubert. Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients and is different in gender. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1935. doi:10.1158/1538-7445.AM2013-1935" @default.
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- W2069049756 date "2013-04-15" @default.
- W2069049756 modified "2023-10-08" @default.
- W2069049756 title "Abstract 1935: Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients and is different in gender." @default.
- W2069049756 doi "https://doi.org/10.1158/1538-7445.am2013-1935" @default.
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