FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069054312> ?p ?o ?g. }

• W2069054312 endingPage "1735" @default.
• W2069054312 startingPage "1727" @default.
• W2069054312 abstract "Intracellular proteins are degraded by a number of proteases, including the ubiquitin-proteasome pathway (UPP). Impairments in the UPP occur during the aging of a variety of tissues, although little is known in regards to age-related alterations to the UPP during the aging of adipose tissue. The UPP is known to be involved in regulating the differentiation of a variety of cell types, although the potential changes in the UPP during adipose differentiation have not been fully elucidated. How the UPP is altered in aging adipose tissue and adipocyte differentiation and the effects of proteasome inhibition on adipocyte homeostasis and differentiation are critical issues to elucidate experimentally. Adipogenesis continues throughout the life of adipose tissue, with continual differentiation of preadipocytes essential to maintaining tissue function during aging, and UPP alterations in mature adipocytes are likely to directly modulate adipose function during aging. In this study we demonstrate that aging induces alterations in the activity and expression of principal components of the UPP. Additionally, we show that multiple changes in the UPP occur during the differentiation of 3T3-L1 cells into adipocytes. In vitro data link observed UPP alterations to increased levels of oxidative stress and altered adipose biology relevant to both aging and differentiation. Taken together, these data demonstrate that changes in the UPP occur in response to adipose aging and adipogenesis and strongly suggest that proteasome inhibition is sufficient to decrease adipose differentiation, as well as increasing oxidative stress in mature adipocytes, both of which probably promote deleterious effects on adipose aging." @default.
• W2069054312 created "2016-06-24" @default.
• W2069054312 creator A5010902028 @default.
• W2069054312 creator A5011049890 @default.
• W2069054312 creator A5021019207 @default.
• W2069054312 creator A5022920715 @default.
• W2069054312 creator A5031201168 @default.
• W2069054312 creator A5053261329 @default.
• W2069054312 creator A5054890154 @default.
• W2069054312 date "2011-11-01" @default.
• W2069054312 modified "2023-10-16" @default.
• W2069054312 title "Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress" @default.
• W2069054312 cites W165358662 @default.
• W2069054312 cites W1720651638 @default.
• W2069054312 cites W1769202563 @default.
• W2069054312 cites W1832030339 @default.
• W2069054312 cites W1967320088 @default.
• W2069054312 cites W1970115972 @default.
• W2069054312 cites W1974545118 @default.
• W2069054312 cites W1981796782 @default.
• W2069054312 cites W1982982813 @default.
• W2069054312 cites W1989833382 @default.
• W2069054312 cites W1990541205 @default.
• W2069054312 cites W1998455345 @default.
• W2069054312 cites W2001728435 @default.
• W2069054312 cites W2005875118 @default.
• W2069054312 cites W2008352575 @default.
• W2069054312 cites W2017264236 @default.
• W2069054312 cites W2025250061 @default.
• W2069054312 cites W2025858860 @default.
• W2069054312 cites W2030977583 @default.
• W2069054312 cites W2032514151 @default.
• W2069054312 cites W2035892035 @default.
• W2069054312 cites W2044320834 @default.
• W2069054312 cites W2045823513 @default.
• W2069054312 cites W2047983287 @default.
• W2069054312 cites W2052446138 @default.
• W2069054312 cites W2052978658 @default.
• W2069054312 cites W2056956751 @default.
• W2069054312 cites W2057491765 @default.
• W2069054312 cites W2058902172 @default.
• W2069054312 cites W2065789432 @default.
• W2069054312 cites W2067730748 @default.
• W2069054312 cites W2069558973 @default.
• W2069054312 cites W2072718213 @default.
• W2069054312 cites W2076041773 @default.
• W2069054312 cites W2076701882 @default.
• W2069054312 cites W2083883947 @default.
• W2069054312 cites W2088499531 @default.
• W2069054312 cites W2089033608 @default.
• W2069054312 cites W2091272291 @default.
• W2069054312 cites W2091973116 @default.
• W2069054312 cites W2092783052 @default.
• W2069054312 cites W2093529069 @default.
• W2069054312 cites W2104298355 @default.
• W2069054312 cites W2106142655 @default.
• W2069054312 cites W2110240348 @default.
• W2069054312 cites W2123208560 @default.
• W2069054312 cites W2137275982 @default.
• W2069054312 cites W2141743897 @default.
• W2069054312 cites W2147890916 @default.
• W2069054312 cites W2151712341 @default.
• W2069054312 cites W2154906695 @default.
• W2069054312 cites W2159622967 @default.
• W2069054312 cites W2166415858 @default.
• W2069054312 cites W2178503716 @default.
• W2069054312 cites W4297170663 @default.
• W2069054312 doi "https://doi.org/10.1016/j.freeradbiomed.2011.08.001" @default.
• W2069054312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3378646" @default.
• W2069054312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21871954" @default.
• W2069054312 hasPublicationYear "2011" @default.
• W2069054312 type Work @default.
• W2069054312 sameAs 2069054312 @default.
• W2069054312 citedByCount "29" @default.
• W2069054312 countsByYear W20690543122012 @default.
• W2069054312 countsByYear W20690543122014 @default.
• W2069054312 countsByYear W20690543122015 @default.
• W2069054312 countsByYear W20690543122016 @default.
• W2069054312 countsByYear W20690543122017 @default.
• W2069054312 countsByYear W20690543122020 @default.
• W2069054312 countsByYear W20690543122022 @default.
• W2069054312 countsByYear W20690543122023 @default.
• W2069054312 crossrefType "journal-article" @default.
• W2069054312 hasAuthorship W2069054312A5010902028 @default.
• W2069054312 hasAuthorship W2069054312A5011049890 @default.
• W2069054312 hasAuthorship W2069054312A5021019207 @default.
• W2069054312 hasAuthorship W2069054312A5022920715 @default.
• W2069054312 hasAuthorship W2069054312A5031201168 @default.
• W2069054312 hasAuthorship W2069054312A5053261329 @default.
• W2069054312 hasAuthorship W2069054312A5054890154 @default.
• W2069054312 hasBestOaLocation W20690543122 @default.
• W2069054312 hasConcept C104317684 @default.
• W2069054312 hasConcept C122927707 @default.
• W2069054312 hasConcept C126322002 @default.
• W2069054312 hasConcept C134018914 @default.
• W2069054312 hasConcept C148738053 @default.
• W2069054312 hasConcept C171089720 @default.
• W2069054312 hasConcept C185592680 @default.

• next