Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069059657> ?p ?o ?g. }
- W2069059657 endingPage "6083" @default.
- W2069059657 startingPage "6078" @default.
- W2069059657 abstract "ABSTRACT A longstanding enigmatic feature of the group 1 coronaviruses is the uncleaved phenotype of their spike protein, an exceptional property among class I fusion proteins. Here, however, we show that some group 1 coronavirus spike proteins carry a furin enzyme recognition motif and can actually be cleaved, as demonstrated for a feline coronavirus. Interestingly, this feature can be lost during cell culture adaptation by a single mutation in the cleavage motif; this, however, preserves a heparan sulfate binding motif and renders infection by the virus heparan sulfate dependent. We identified a similar cell culture adaptation for the human coronavirus OC43." @default.
- W2069059657 created "2016-06-24" @default.
- W2069059657 creator A5000266713 @default.
- W2069059657 creator A5032673596 @default.
- W2069059657 creator A5048117410 @default.
- W2069059657 creator A5060049651 @default.
- W2069059657 creator A5063025929 @default.
- W2069059657 creator A5067826092 @default.
- W2069059657 creator A5075787110 @default.
- W2069059657 date "2008-06-15" @default.
- W2069059657 modified "2023-10-05" @default.
- W2069059657 title "Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation" @default.
- W2069059657 cites W1491507080 @default.
- W2069059657 cites W1545952535 @default.
- W2069059657 cites W1967608763 @default.
- W2069059657 cites W1972419862 @default.
- W2069059657 cites W1974898808 @default.
- W2069059657 cites W1981726862 @default.
- W2069059657 cites W1995670529 @default.
- W2069059657 cites W1996803605 @default.
- W2069059657 cites W1997482909 @default.
- W2069059657 cites W2005411001 @default.
- W2069059657 cites W2006286994 @default.
- W2069059657 cites W2015179413 @default.
- W2069059657 cites W2015936607 @default.
- W2069059657 cites W2017415583 @default.
- W2069059657 cites W2026445898 @default.
- W2069059657 cites W2036256939 @default.
- W2069059657 cites W2039663472 @default.
- W2069059657 cites W2054941036 @default.
- W2069059657 cites W2068673200 @default.
- W2069059657 cites W2070012915 @default.
- W2069059657 cites W2071189045 @default.
- W2069059657 cites W2080149068 @default.
- W2069059657 cites W2080807893 @default.
- W2069059657 cites W2087244429 @default.
- W2069059657 cites W2089296732 @default.
- W2069059657 cites W2097188280 @default.
- W2069059657 cites W2098939618 @default.
- W2069059657 cites W2101443182 @default.
- W2069059657 cites W2101666840 @default.
- W2069059657 cites W2106091974 @default.
- W2069059657 cites W2111412754 @default.
- W2069059657 cites W2113861885 @default.
- W2069059657 cites W2126980050 @default.
- W2069059657 cites W2127939214 @default.
- W2069059657 cites W2130892150 @default.
- W2069059657 cites W2135883823 @default.
- W2069059657 cites W2139090502 @default.
- W2069059657 cites W2140823754 @default.
- W2069059657 cites W2144429336 @default.
- W2069059657 cites W2152912823 @default.
- W2069059657 cites W2156082494 @default.
- W2069059657 cites W2158266152 @default.
- W2069059657 cites W2158367532 @default.
- W2069059657 cites W2160524382 @default.
- W2069059657 cites W2168359445 @default.
- W2069059657 cites W4251144546 @default.
- W2069059657 cites W4376596386 @default.
- W2069059657 doi "https://doi.org/10.1128/jvi.00074-08" @default.
- W2069059657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2395124" @default.
- W2069059657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18400867" @default.
- W2069059657 hasPublicationYear "2008" @default.
- W2069059657 type Work @default.
- W2069059657 sameAs 2069059657 @default.
- W2069059657 citedByCount "99" @default.
- W2069059657 countsByYear W20690596572012 @default.
- W2069059657 countsByYear W20690596572013 @default.
- W2069059657 countsByYear W20690596572014 @default.
- W2069059657 countsByYear W20690596572015 @default.
- W2069059657 countsByYear W20690596572016 @default.
- W2069059657 countsByYear W20690596572017 @default.
- W2069059657 countsByYear W20690596572018 @default.
- W2069059657 countsByYear W20690596572019 @default.
- W2069059657 countsByYear W20690596572020 @default.
- W2069059657 countsByYear W20690596572021 @default.
- W2069059657 countsByYear W20690596572022 @default.
- W2069059657 countsByYear W20690596572023 @default.
- W2069059657 crossrefType "journal-article" @default.
- W2069059657 hasAuthorship W2069059657A5000266713 @default.
- W2069059657 hasAuthorship W2069059657A5032673596 @default.
- W2069059657 hasAuthorship W2069059657A5048117410 @default.
- W2069059657 hasAuthorship W2069059657A5060049651 @default.
- W2069059657 hasAuthorship W2069059657A5063025929 @default.
- W2069059657 hasAuthorship W2069059657A5067826092 @default.
- W2069059657 hasAuthorship W2069059657A5075787110 @default.
- W2069059657 hasBestOaLocation W20690596572 @default.
- W2069059657 hasConcept C103038307 @default.
- W2069059657 hasConcept C104317684 @default.
- W2069059657 hasConcept C127716648 @default.
- W2069059657 hasConcept C142724271 @default.
- W2069059657 hasConcept C143065580 @default.
- W2069059657 hasConcept C1491633281 @default.
- W2069059657 hasConcept C151730666 @default.
- W2069059657 hasConcept C153911025 @default.
- W2069059657 hasConcept C159047783 @default.
- W2069059657 hasConcept C175156509 @default.
- W2069059657 hasConcept C181199279 @default.