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- W2069059812 abstract "The effect of various factors which block electrical activity have been tested on the efflux of K from the electroplax of Electrophorus electricus. 1. Increase of K concentration from 5 mM to 110 mM in the Ringer's solution bathing the innervated site of the electroplax, with corresponding decrease in Na concentration, caused an immediate increase of the K efflux. Surprisingly, this increased rate was maintained for a few minutes only and then returned to about the original level. When the K concentration in the outside fluid was raised from 110 to 165 mM, no further change of the rate of K efflux was observed. 2. Addition of d-tubocurarine in high concentrations (1 mg/ml) did not affect the efflux, thus suggesting that the increased efflux with a high external K concentration must be attributed to an increased flow of K ions across the conducting membrane. 3. When the Ringer K concentration was increased to 110 or 165 mM, without corresponding removal of Na, the effects observed with this hypertonic solution were essentially the same. 4. Exposure of the electroplax to either carbamylcholine or to pyridine aldoxime dodeciodide, both known to block electrical activity and to depolarize the conducting membrane, as does high K concentration, affected the rate of efflux of K in essentially the same way as exposure to high K concentration. 5. In contrast, replacement of external Na by either sucrose or choline, in which case activity is blocked without depolarization, did not affect the rate of potassium efflux." @default.
- W2069059812 created "2016-06-24" @default.
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- W2069059812 date "1960-01-01" @default.
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- W2069059812 title "The effect of blocking electrical activity on the efflux of potassium from electroplax" @default.
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- W2069059812 doi "https://doi.org/10.1016/0006-3002(60)91456-6" @default.
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