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- W2069061424 abstract "Interferon beta-1b (IFNbeta-1b) is effective in reducing the frequency of exacerbations in patients with relapsing-remitting multiple sclerosis (RRMS). Recently, a study suggested that treatment with IFNbeta-1b may place MS patients at risk of exacerbations by increasing interferon-gamma (IFNgamma)-secreting cells in the blood early after onset of treatment. We conducted a retrospective study in 192 RRMS patients treated with IFNbeta-1b. We did not observe an increase in the frequency of exacerbations early after the onset of treatment and suggest that the IFNgamma-secreting cell surge linked to the onset of treatment with IFNbeta-1b may not be clinically significant." @default.
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- W2069061424 date "1998-07-01" @default.
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- W2069061424 title "Incidence of exacerbations in the first 90 days of treatment with recombinant human interferon ?-1b in patients with relapsing-remitting multiple sclerosis" @default.
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- W2069061424 doi "https://doi.org/10.1002/ana.410440123" @default.
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