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• W2069062014 startingPage "9" @default.
• W2069062014 abstract "Chronic anal fissure (CAF) is a painful tear or crack which occurs in the anoderm. The optimal algorithm of therapy for CAF is still debated. Lateral internal sphincterotomy (LIS) is a surgical treatment, considered as the 'gold standard' therapy for CAF. It relieves CAF symptoms with a high rate of healing. Chemical sphincterotomy (CS) with nitrates, calcium blockers or botulinum toxin (BTX) is safe, with the rapid relief of pain, mild side-effects and no risk of surgery or anesthesia, but is a statistically less effective therapy for CAF than LIS. This article considers if aggressive treatment should only be offered to patients who fail pharmacological sphincterotomy. Aspects of anal fissure etiology, epidemiology and pathophysiology are considered with their meaning for further management of CAF. A molecular model of chemical interdependence significant for the chemistry of CAF healing is examined. Its application may influence the development of optimal therapy for CAF. BTX is currently considered the most effective type of CS and discussion in this article scrutinizes this method specifically. Although the effectiveness of BTX vs. LIS has been discussed, the essential focus of the article concerns identifying the best therapy application for anal fissure. Elements are presented which may help us to predict CAF healing. They provide rationale for the expansion of the CAF therapy algorithm. Ethical and economic factors are also considered in brief. As long as the patient is willing to accept the potential risk of fecal incontinence, we have grounds for the 'gold standard' (LIS) as the first-line treatment for CAF. The author concludes that, when the diagnosis of the anal fissure is established, CS should be considered for both ethical and economic reasons. He is convinced that a greater understanding and recognition of benign anal disorders by the GP and a proactive involvement at the point of initial diagnosis would facilitate the consideration of CS at an earlier, more practical stage with improved outcomes for the patient." @default.
• W2069062014 created "2016-06-24" @default.
• W2069062014 creator A5053344371 @default.
• W2069062014 date "2011-01-01" @default.
• W2069062014 modified "2023-10-17" @default.
• W2069062014 title "Identifying the best therapy for chronic anal fissure" @default.
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• W2069062014 cites W1970800923 @default.
• W2069062014 cites W1974807287 @default.
• W2069062014 cites W1975901734 @default.
• W2069062014 cites W1978142864 @default.
• W2069062014 cites W1982089546 @default.
• W2069062014 cites W1985848913 @default.
• W2069062014 cites W1988176251 @default.
• W2069062014 cites W1988903362 @default.
• W2069062014 cites W1988962964 @default.
• W2069062014 cites W1989394066 @default.
• W2069062014 cites W1991904281 @default.
• W2069062014 cites W1993384699 @default.
• W2069062014 cites W1993456620 @default.
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• W2069062014 cites W2005405395 @default.
• W2069062014 cites W2005772196 @default.
• W2069062014 cites W2006214871 @default.
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• W2069062014 cites W2022811299 @default.
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• W2069062014 doi "https://doi.org/10.4292/wjgpt.v2.i2.9" @default.
• W2069062014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3091162" @default.
• W2069062014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21577312" @default.
• W2069062014 hasPublicationYear "2011" @default.
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