FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069063498> ?p ?o ?g. }

• W2069063498 endingPage "1525" @default.
• W2069063498 startingPage "1520" @default.
• W2069063498 abstract "Grb7 has potential importance in the progression of cancer. We have previously identified a novel peptide that binds to the SH2 domain of Grb7 and inhibits its association with several different receptor tyrosine kinases. We have synthesised the Grb7 peptide, G7-18NATE, with two different cell penetrating peptides, Penetratin and Tat. In this study, we have shown that both Penetratin- and Tat-conjugated G7-18NATE peptides are able to inhibit the proliferation of SK-BR-3, ZR-75-30, MDA-MB-361 and MDA-MB-231 breast cancer cells. There was no significant effects on breast cancer MCF-7cells, non-malignant MCF 10A or 3T3 cells. In addition, there was no significant inhibition of proliferation by Penetratin or Tat alone or by their conjugates with arbitrary peptide sequence in any of the cell lines tested. We determined the EC50 of G7-18NATE-P peptide for SK-BR-3 cell proliferation to be 7.663 × 10−6 M. Co-treatment of G7-18NATE-P peptide plus Doxorubicin in SK-BR-3 breast cancer cells resulted in an additional inhibition of proliferation, resulting in 56 and 84% decreases in the Doxorubicin EC50 value in the presence of 5 × 10−6 and 1.0 × 10−5 M G7-18NATE-P peptide, respectively. Importantly, the co-treatment with Doxorubicin and the delivery peptide did not change the Doxorubicin EC50. Since Grb7 associates with ErbB2, we assessed whether the peptide inhibitor would have a combined effect with a molecule that targets ErbB2, Herceptin. Co-treatment of Herceptin plus 1.0 × 10−5 M G7-18NATE-P peptide in SK-BR-3 cells resulted in a 46% decrease in the Herceptin EC50 value and no decrease following the co-treatment with Herceptin and penetratin alone. This Grb7 peptide has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules." @default.
• W2069063498 created "2016-06-24" @default.
• W2069063498 creator A5041123859 @default.
• W2069063498 creator A5042010762 @default.
• W2069063498 creator A5046221788 @default.
• W2069063498 creator A5046887285 @default.
• W2069063498 creator A5081120943 @default.
• W2069063498 date "2007-04-10" @default.
• W2069063498 modified "2023-10-07" @default.
• W2069063498 title "Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells" @default.
• W2069063498 cites W1550594329 @default.
• W2069063498 cites W1564868464 @default.
• W2069063498 cites W1606090394 @default.
• W2069063498 cites W1890809256 @default.
• W2069063498 cites W1973724537 @default.
• W2069063498 cites W1975348357 @default.
• W2069063498 cites W1977958044 @default.
• W2069063498 cites W1985786420 @default.
• W2069063498 cites W1990353912 @default.
• W2069063498 cites W1990426099 @default.
• W2069063498 cites W1995842543 @default.
• W2069063498 cites W1998032903 @default.
• W2069063498 cites W2000092807 @default.
• W2069063498 cites W2001493784 @default.
• W2069063498 cites W2004490932 @default.
• W2069063498 cites W2014032634 @default.
• W2069063498 cites W2021397240 @default.
• W2069063498 cites W2030273692 @default.
• W2069063498 cites W2053673624 @default.
• W2069063498 cites W2071516872 @default.
• W2069063498 cites W2071892232 @default.
• W2069063498 cites W2096199069 @default.
• W2069063498 cites W2098849944 @default.
• W2069063498 cites W2146592486 @default.
• W2069063498 cites W2161589433 @default.
• W2069063498 cites W2166245471 @default.
• W2069063498 cites W2168631900 @default.
• W2069063498 cites W2222638000 @default.
• W2069063498 cites W2249984074 @default.
• W2069063498 cites W4237773712 @default.
• W2069063498 cites W83212480 @default.
• W2069063498 doi "https://doi.org/10.1038/sj.bjc.6603732" @default.
• W2069063498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2359946" @default.
• W2069063498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17426702" @default.
• W2069063498 hasPublicationYear "2007" @default.
• W2069063498 type Work @default.
• W2069063498 sameAs 2069063498 @default.
• W2069063498 citedByCount "67" @default.
• W2069063498 countsByYear W20690634982012 @default.
• W2069063498 countsByYear W20690634982013 @default.
• W2069063498 countsByYear W20690634982014 @default.
• W2069063498 countsByYear W20690634982015 @default.
• W2069063498 countsByYear W20690634982016 @default.
• W2069063498 countsByYear W20690634982017 @default.
• W2069063498 countsByYear W20690634982018 @default.
• W2069063498 countsByYear W20690634982019 @default.
• W2069063498 countsByYear W20690634982020 @default.
• W2069063498 countsByYear W20690634982021 @default.
• W2069063498 countsByYear W20690634982023 @default.
• W2069063498 crossrefType "journal-article" @default.
• W2069063498 hasAuthorship W2069063498A5041123859 @default.
• W2069063498 hasAuthorship W2069063498A5042010762 @default.
• W2069063498 hasAuthorship W2069063498A5046221788 @default.
• W2069063498 hasAuthorship W2069063498A5046887285 @default.
• W2069063498 hasAuthorship W2069063498A5081120943 @default.
• W2069063498 hasBestOaLocation W20690634981 @default.
• W2069063498 hasConcept C121608353 @default.
• W2069063498 hasConcept C126322002 @default.
• W2069063498 hasConcept C170493617 @default.
• W2069063498 hasConcept C185592680 @default.
• W2069063498 hasConcept C2776694085 @default.
• W2069063498 hasConcept C2779281246 @default.
• W2069063498 hasConcept C2779707156 @default.
• W2069063498 hasConcept C2779786085 @default.
• W2069063498 hasConcept C2781303535 @default.
• W2069063498 hasConcept C42362537 @default.
• W2069063498 hasConcept C502942594 @default.
• W2069063498 hasConcept C530470458 @default.
• W2069063498 hasConcept C54355233 @default.
• W2069063498 hasConcept C55493867 @default.
• W2069063498 hasConcept C62112901 @default.
• W2069063498 hasConcept C71924100 @default.
• W2069063498 hasConcept C81885089 @default.
• W2069063498 hasConcept C86803240 @default.
• W2069063498 hasConcept C96232424 @default.
• W2069063498 hasConcept C98274493 @default.
• W2069063498 hasConceptScore W2069063498C121608353 @default.
• W2069063498 hasConceptScore W2069063498C126322002 @default.
• W2069063498 hasConceptScore W2069063498C170493617 @default.
• W2069063498 hasConceptScore W2069063498C185592680 @default.
• W2069063498 hasConceptScore W2069063498C2776694085 @default.
• W2069063498 hasConceptScore W2069063498C2779281246 @default.
• W2069063498 hasConceptScore W2069063498C2779707156 @default.
• W2069063498 hasConceptScore W2069063498C2779786085 @default.
• W2069063498 hasConceptScore W2069063498C2781303535 @default.
• W2069063498 hasConceptScore W2069063498C42362537 @default.
• W2069063498 hasConceptScore W2069063498C502942594 @default.
• W2069063498 hasConceptScore W2069063498C530470458 @default.

• next