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- W2069064104 abstract "To evaluate differences in abdominal aortic aneurysm (AAA) shrinkage among hospitals following protocol-driven patient selection and using endografts from a single manufacturer.Standardized inclusion criteria for the Talent endograft multicenter trials included AAA diameter >/=40 mm and proximal neck limits of length >/=5 mm, diameter 14 to 32 mm, and angle </=60 degrees. AAA reporting standards categories were used to classify distal aorta and common iliac artery involvement. Serial computed tomographic scans through 12-month follow-up were examined by independent core laboratory review. Significant shrinkage was defined as a >/=5-mm decrease in the AAA largest minor axis diameter. Trial sites with >10 complete study cases were selected for stepwise logistic regression analysis. In the 13 trial sites meeting this criterion, 323 patients (mean age 74; 93% men) were treated for aneurysms with a mean pretreatment diameter of 53 mm.At 12 months, significant AAA shrinkage occurred in 192 (59%) cases. The AAA shrinkage rate was 71% to 82% at 3 sites, 60% to 64% at 4 sites, 45% to 50% at 4 sites, and 35% and 27% at the 2 remaining sites. In the multivariate analysis, the hospital site showed a strong, independent association with aneurysm shrinkage (p<0.04). Neck and pretreatment AAA diameters were also found to be important factors (p<0.04). Age, gender, AAA classification, neck length, and angle were not significant correlates. Sixty-four (20%) endoleaks (29 type I, 34 type II, and 1 type III) were observed. The incidence of proximal endoleak was significantly different among sites (p<0.001) and highest in the 3 sites with the lowest AAA shrinkage rate.AAA shrinkage rates vary significantly among hospitals using the same endograft and protocol-defined patient selection criteria. Site-specific factors appear to be an important variable leading to successful endograft repair, as defined by post-endograft aneurysm shrinkage." @default.
- W2069064104 created "2016-06-24" @default.
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- W2069064104 date "2004-08-01" @default.
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- W2069064104 title "Post-Endograft Abdominal Aortic Aneurysm Shrinkage Varies Among Hospitals:Observations From Multicenter Trials" @default.
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- W2069064104 doi "https://doi.org/10.1583/04-1241.1" @default.
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