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- W2069067369 abstract "Spinocerebellar ataxia type 2 (SCA2) is a human neurodegenerative disease caused by mutation in the ataxin-2 gene on human chromosome 12. Ataxin-2 is a protein of unknown function. We identified a new family of proteins designated as ataxin-2-related proteins (A2RPs), with high homology at the nucleotide and predicted amino acid levels. Ataxin-2 and A2RP are proteins highly conserved in evolution with orthologs in mouse, cattle, pig, frog, and plants. A2RP has several isoforms with different C-terminal domains. The longest isoform is composed of 1051 amino acids and has widespread expression in human tissues by Northern and Western blot analyses." @default.
- W2069067369 created "2016-06-24" @default.
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- W2069067369 date "2003-12-01" @default.
- W2069067369 modified "2023-09-29" @default.
- W2069067369 title "Identification and expression of the gene for human ataxin-2-related protein on chromosome 16" @default.
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- W2069067369 doi "https://doi.org/10.1016/s0014-4886(03)00287-5" @default.
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