Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069067505> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2069067505 endingPage "PL12" @default.
- W2069067505 startingPage "PL7" @default.
- W2069067505 abstract "Neuropeptide Y (NPY) and peptide YY (PYY) are homologous 36 amino acid amidated peptides that often, but not always, exert similar actions and binding profiles. The present study of cultured cells confirms that both peptides as well as radioiodinated analogs, i.e. 125I-Bolton-Hunter-NPY (125I-BH-NPY) and 125I-peptide YY (125I-PYY), show high affinity to binding sites/receptors of the previously proposed Y1- and Y2-subtypes, selectively expressed by the human neuroblastoma cell lines, SK-N-MC and SK-N-BE(2), respectively. In contrast, bovine adrenal chromaffin cells did not bind 125I-PYY, while displaying high affinity 125I-BH-NPY sites, and may therefore represent a cell type expressing a recently proposed Y3-type of (NPY-preferring) receptors. Several non-labeled fragments/analogs have been used in displacement experiments to further characterize the structural requirements for Y1-, Y2-, and Y3-type binding. In every instance, specific binding was reduced by addition of 5'-guanylylimidodiphosphate [Gpp(NH)p], indicating that the three receptor subtypes belong to the G-protein-coupled superfamily of receptors. Moreover, in both neuroblastoma cell lines, the peptides elicited, with appropriate orders of potency, reduction of forskolin-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) accumulation. Finally, NPY-evoked 45Ca2+ influx was observed in SK-N-MC and in chromaffin cells. A common dual coupling mechanism of NPY/PYY receptors, i.e. to reduction of cAMP and to Ca2+ elevation, is therefore suggested to exist, although both phenomena could not be demonstrated in every cell type." @default.
- W2069067505 created "2016-06-24" @default.
- W2069067505 creator A5063089135 @default.
- W2069067505 creator A5085264920 @default.
- W2069067505 creator A5086750022 @default.
- W2069067505 date "1992-01-01" @default.
- W2069067505 modified "2023-10-18" @default.
- W2069067505 title "Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY" @default.
- W2069067505 cites W1604152302 @default.
- W2069067505 cites W1662683252 @default.
- W2069067505 cites W1987863605 @default.
- W2069067505 cites W1988628530 @default.
- W2069067505 cites W2001034339 @default.
- W2069067505 cites W2005677996 @default.
- W2069067505 cites W2036996842 @default.
- W2069067505 cites W2042069750 @default.
- W2069067505 cites W2053807193 @default.
- W2069067505 cites W2060422151 @default.
- W2069067505 cites W2065219927 @default.
- W2069067505 cites W2074589564 @default.
- W2069067505 cites W2280018118 @default.
- W2069067505 cites W4247709183 @default.
- W2069067505 doi "https://doi.org/10.1016/0024-3205(92)90342-m" @default.
- W2069067505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1310131" @default.
- W2069067505 hasPublicationYear "1992" @default.
- W2069067505 type Work @default.
- W2069067505 sameAs 2069067505 @default.
- W2069067505 citedByCount "161" @default.
- W2069067505 countsByYear W20690675052012 @default.
- W2069067505 countsByYear W20690675052014 @default.
- W2069067505 countsByYear W20690675052015 @default.
- W2069067505 countsByYear W20690675052018 @default.
- W2069067505 countsByYear W20690675052019 @default.
- W2069067505 countsByYear W20690675052023 @default.
- W2069067505 crossrefType "journal-article" @default.
- W2069067505 hasAuthorship W2069067505A5063089135 @default.
- W2069067505 hasAuthorship W2069067505A5085264920 @default.
- W2069067505 hasAuthorship W2069067505A5086750022 @default.
- W2069067505 hasConcept C118303440 @default.
- W2069067505 hasConcept C126322002 @default.
- W2069067505 hasConcept C134018914 @default.
- W2069067505 hasConcept C153911025 @default.
- W2069067505 hasConcept C170493617 @default.
- W2069067505 hasConcept C185592680 @default.
- W2069067505 hasConcept C2779276759 @default.
- W2069067505 hasConcept C2779281246 @default.
- W2069067505 hasConcept C2780796126 @default.
- W2069067505 hasConcept C54355233 @default.
- W2069067505 hasConcept C55493867 @default.
- W2069067505 hasConcept C56191518 @default.
- W2069067505 hasConcept C71924100 @default.
- W2069067505 hasConcept C81885089 @default.
- W2069067505 hasConcept C86803240 @default.
- W2069067505 hasConcept C93984277 @default.
- W2069067505 hasConceptScore W2069067505C118303440 @default.
- W2069067505 hasConceptScore W2069067505C126322002 @default.
- W2069067505 hasConceptScore W2069067505C134018914 @default.
- W2069067505 hasConceptScore W2069067505C153911025 @default.
- W2069067505 hasConceptScore W2069067505C170493617 @default.
- W2069067505 hasConceptScore W2069067505C185592680 @default.
- W2069067505 hasConceptScore W2069067505C2779276759 @default.
- W2069067505 hasConceptScore W2069067505C2779281246 @default.
- W2069067505 hasConceptScore W2069067505C2780796126 @default.
- W2069067505 hasConceptScore W2069067505C54355233 @default.
- W2069067505 hasConceptScore W2069067505C55493867 @default.
- W2069067505 hasConceptScore W2069067505C56191518 @default.
- W2069067505 hasConceptScore W2069067505C71924100 @default.
- W2069067505 hasConceptScore W2069067505C81885089 @default.
- W2069067505 hasConceptScore W2069067505C86803240 @default.
- W2069067505 hasConceptScore W2069067505C93984277 @default.
- W2069067505 hasIssue "4" @default.
- W2069067505 hasLocation W20690675051 @default.
- W2069067505 hasLocation W20690675052 @default.
- W2069067505 hasOpenAccess W2069067505 @default.
- W2069067505 hasPrimaryLocation W20690675051 @default.
- W2069067505 hasRelatedWork W1545231006 @default.
- W2069067505 hasRelatedWork W2005677996 @default.
- W2069067505 hasRelatedWork W2033902814 @default.
- W2069067505 hasRelatedWork W2052337550 @default.
- W2069067505 hasRelatedWork W2086048037 @default.
- W2069067505 hasRelatedWork W2087728297 @default.
- W2069067505 hasRelatedWork W2091225404 @default.
- W2069067505 hasRelatedWork W2107263774 @default.
- W2069067505 hasRelatedWork W2114765598 @default.
- W2069067505 hasRelatedWork W2625880411 @default.
- W2069067505 hasVolume "50" @default.
- W2069067505 isParatext "false" @default.
- W2069067505 isRetracted "false" @default.
- W2069067505 magId "2069067505" @default.
- W2069067505 workType "article" @default.