Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069069164> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2069069164 endingPage "59" @default.
- W2069069164 startingPage "50" @default.
- W2069069164 abstract "The tissue disposition of perchloroethylene (PCE) was characterized experimentally in rats in order to (1) obtain input parameters from in vivo data for the development of a physiologically based pharmacokinetic (PBPK) model, and (2) use the PBPK model to predict the deposition of PCE in a variety of tissues following inhalation exposure. For the derivation of model input parameters, male Sprague-Dawley rats received a single bolus of 10 mg PCE/kg body wt in polyethylene glycol 400 by ia injection through an indwelling carotid arterial cannula. Other male Sprague-Dawley rats inhaled 500 ppm PCE for 2 hr in dynamic exposure inhalation chambers. Serial samples of brain, liver, kidney, lung, heart, skeletal muscle, perirenal fat, and blood were taken for up to 72 hr following ia injection, during the 2-hr inhalation exposure, and for up to 72 hr postexposure. Blood and tissue PCE concentrations were analyzed using a gas chromatography headspace technique. Following ia administration, the tissues exhibited similar terminal elimination half-lives (t1/2). As comparable tissue t1/2 are consistent with a blood-flow-limited model, tissue:blood partition coefficients were calculated for noneliminating compartments by division of the area under the tissue concentration-time curve (AUC) by the blood AUC. Liver PCE concentration versus time data were employed in the calculation of in vivo metabolic rate constants. A PBPK model was developed using these parameters derived from the ia data set and used to predict tissue PCE concentrations during and following PCE inhalation. Predicted tissue levels were in close agreement with the levels measured over time in the seven tissues and in blood. Tissue concentration-time data can thus provide valuable input for parameter estimation and for validation of PBPK model simulations, as long as independent in vivo data sets are used for each step." @default.
- W2069069164 created "2016-06-24" @default.
- W2069069164 creator A5001446431 @default.
- W2069069164 creator A5002470049 @default.
- W2069069164 creator A5004674879 @default.
- W2069069164 creator A5016659631 @default.
- W2069069164 creator A5019546422 @default.
- W2069069164 creator A5061302418 @default.
- W2069069164 date "1994-09-01" @default.
- W2069069164 modified "2023-09-23" @default.
- W2069069164 title "Development of a Physiologically-Based Pharmacokinetic Model for Perchloroethylene Using Tissue Concentration-Time Data" @default.
- W2069069164 doi "https://doi.org/10.1006/taap.1994.1179" @default.
- W2069069164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8079354" @default.
- W2069069164 hasPublicationYear "1994" @default.
- W2069069164 type Work @default.
- W2069069164 sameAs 2069069164 @default.
- W2069069164 citedByCount "24" @default.
- W2069069164 countsByYear W20690691642012 @default.
- W2069069164 countsByYear W20690691642013 @default.
- W2069069164 countsByYear W20690691642014 @default.
- W2069069164 countsByYear W20690691642015 @default.
- W2069069164 crossrefType "journal-article" @default.
- W2069069164 hasAuthorship W2069069164A5001446431 @default.
- W2069069164 hasAuthorship W2069069164A5002470049 @default.
- W2069069164 hasAuthorship W2069069164A5004674879 @default.
- W2069069164 hasAuthorship W2069069164A5016659631 @default.
- W2069069164 hasAuthorship W2069069164A5019546422 @default.
- W2069069164 hasAuthorship W2069069164A5061302418 @default.
- W2069069164 hasConcept C112705442 @default.
- W2069069164 hasConcept C126322002 @default.
- W2069069164 hasConcept C150903083 @default.
- W2069069164 hasConcept C185592680 @default.
- W2069069164 hasConcept C185867374 @default.
- W2069069164 hasConcept C192552737 @default.
- W2069069164 hasConcept C195289149 @default.
- W2069069164 hasConcept C207001950 @default.
- W2069069164 hasConcept C2776954882 @default.
- W2069069164 hasConcept C2777477808 @default.
- W2069069164 hasConcept C2779537118 @default.
- W2069069164 hasConcept C2779777708 @default.
- W2069069164 hasConcept C2780091579 @default.
- W2069069164 hasConcept C42219234 @default.
- W2069069164 hasConcept C43617362 @default.
- W2069069164 hasConcept C55493867 @default.
- W2069069164 hasConcept C71924100 @default.
- W2069069164 hasConcept C86803240 @default.
- W2069069164 hasConcept C98274493 @default.
- W2069069164 hasConceptScore W2069069164C112705442 @default.
- W2069069164 hasConceptScore W2069069164C126322002 @default.
- W2069069164 hasConceptScore W2069069164C150903083 @default.
- W2069069164 hasConceptScore W2069069164C185592680 @default.
- W2069069164 hasConceptScore W2069069164C185867374 @default.
- W2069069164 hasConceptScore W2069069164C192552737 @default.
- W2069069164 hasConceptScore W2069069164C195289149 @default.
- W2069069164 hasConceptScore W2069069164C207001950 @default.
- W2069069164 hasConceptScore W2069069164C2776954882 @default.
- W2069069164 hasConceptScore W2069069164C2777477808 @default.
- W2069069164 hasConceptScore W2069069164C2779537118 @default.
- W2069069164 hasConceptScore W2069069164C2779777708 @default.
- W2069069164 hasConceptScore W2069069164C2780091579 @default.
- W2069069164 hasConceptScore W2069069164C42219234 @default.
- W2069069164 hasConceptScore W2069069164C43617362 @default.
- W2069069164 hasConceptScore W2069069164C55493867 @default.
- W2069069164 hasConceptScore W2069069164C71924100 @default.
- W2069069164 hasConceptScore W2069069164C86803240 @default.
- W2069069164 hasConceptScore W2069069164C98274493 @default.
- W2069069164 hasIssue "1" @default.
- W2069069164 hasLocation W20690691641 @default.
- W2069069164 hasLocation W20690691642 @default.
- W2069069164 hasOpenAccess W2069069164 @default.
- W2069069164 hasPrimaryLocation W20690691641 @default.
- W2069069164 hasRelatedWork W1973535044 @default.
- W2069069164 hasRelatedWork W2020325106 @default.
- W2069069164 hasRelatedWork W2064126483 @default.
- W2069069164 hasRelatedWork W2069069164 @default.
- W2069069164 hasRelatedWork W2078828471 @default.
- W2069069164 hasRelatedWork W2086209760 @default.
- W2069069164 hasRelatedWork W2098932414 @default.
- W2069069164 hasRelatedWork W2148104899 @default.
- W2069069164 hasRelatedWork W251012218 @default.
- W2069069164 hasRelatedWork W3156128209 @default.
- W2069069164 hasVolume "128" @default.
- W2069069164 isParatext "false" @default.
- W2069069164 isRetracted "false" @default.
- W2069069164 magId "2069069164" @default.
- W2069069164 workType "article" @default.