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- W2069071431 abstract "Rats that consume a high-protein diet are hyperactive, hyperresponsive to noxious stimuli, and demonstrate elevated basal arousal levels. Although the mechanism involved in dietary protein-induced changes in behavir is unclear, it may involve many changes including abnormal dendrite morphology in the brain. Three groups of rats were pair-fed with isocaloric diets containing 8%, 20% and 50% casein for 4 weeks. Their brains were processed for examination of dendritic spine densities in the frontal, parietal, and entorhinal cortices, the striatum, and the septum. Animals on the 50% casein diet showed increased spine densities in all areas investigated ( P < 0.05), compared to the animals on normal (20%) casein. In contrast, animals maintained on the 8% casein diet showed increased spine densities ( P < 0.05_only in the striatum and entorhinal cortex, and exhibited normal densities in the frontal and parietal cortices, and the medial septum." @default.
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- W2069071431 date "1992-04-01" @default.
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- W2069071431 title "Alterations in dendritic spine density in the rat brain associated with protein malnutrition" @default.
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- W2069071431 doi "https://doi.org/10.1016/0165-3806(92)90090-j" @default.
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