Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069076806> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2069076806 endingPage "11713" @default.
- W2069076806 startingPage "11709" @default.
- W2069076806 abstract "The isoproteins proteolipid protein (PLP) and DM20, the two major integral membrane proteins of central nervous system (CNS) myelin, are encoded by a single gene on the X chromosome and show a different developmental expression pattern. To investigate their functions in myelin structure and myelination, we produced transgenic mice carrying a targeted alteration of the X chromosome-linked Plp gene containing a deletion within exon III, mimicking DM20, and a neo cassette in reverse orientation within intron III. Here we show that the antisense integration of the neo cassette disrupts the expression of the Plp gene. The ultrastructure of the multilayer myelin sheath of all axons in the CNS of hemizygous male or homozygous female PLP/DM20-deficient mice is highly disordered. The apposition of the extracytoplasmic surfaces and thereby the intraperiod dense line is lacking. The disrupted assembly of the myelin sheath leads to a profound reduction of conductance velocities of CNS axons, impairments in neuromotor coordination, and behavioral changes." @default.
- W2069076806 created "2016-06-24" @default.
- W2069076806 creator A5015139078 @default.
- W2069076806 creator A5022672330 @default.
- W2069076806 date "1994-11-22" @default.
- W2069076806 modified "2023-10-16" @default.
- W2069076806 title "Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice." @default.
- W2069076806 cites W197016544 @default.
- W2069076806 cites W1977687052 @default.
- W2069076806 cites W1978077579 @default.
- W2069076806 cites W1979084518 @default.
- W2069076806 cites W1983784464 @default.
- W2069076806 cites W2007088607 @default.
- W2069076806 cites W2017968214 @default.
- W2069076806 cites W2021195940 @default.
- W2069076806 cites W2048438362 @default.
- W2069076806 cites W2061680602 @default.
- W2069076806 cites W2062101337 @default.
- W2069076806 cites W2064598698 @default.
- W2069076806 cites W2083505016 @default.
- W2069076806 cites W2088947153 @default.
- W2069076806 cites W2090205264 @default.
- W2069076806 cites W2134812217 @default.
- W2069076806 cites W2147048169 @default.
- W2069076806 cites W2317298699 @default.
- W2069076806 doi "https://doi.org/10.1073/pnas.91.24.11709" @default.
- W2069076806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/45301" @default.
- W2069076806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7526402" @default.
- W2069076806 hasPublicationYear "1994" @default.
- W2069076806 type Work @default.
- W2069076806 sameAs 2069076806 @default.
- W2069076806 citedByCount "199" @default.
- W2069076806 countsByYear W20690768062012 @default.
- W2069076806 countsByYear W20690768062013 @default.
- W2069076806 countsByYear W20690768062014 @default.
- W2069076806 countsByYear W20690768062015 @default.
- W2069076806 countsByYear W20690768062016 @default.
- W2069076806 countsByYear W20690768062017 @default.
- W2069076806 countsByYear W20690768062018 @default.
- W2069076806 countsByYear W20690768062019 @default.
- W2069076806 countsByYear W20690768062020 @default.
- W2069076806 countsByYear W20690768062021 @default.
- W2069076806 countsByYear W20690768062022 @default.
- W2069076806 countsByYear W20690768062023 @default.
- W2069076806 crossrefType "journal-article" @default.
- W2069076806 hasAuthorship W2069076806A5015139078 @default.
- W2069076806 hasAuthorship W2069076806A5022672330 @default.
- W2069076806 hasBestOaLocation W20690768062 @default.
- W2069076806 hasConcept C102230213 @default.
- W2069076806 hasConcept C104317684 @default.
- W2069076806 hasConcept C141035611 @default.
- W2069076806 hasConcept C153911025 @default.
- W2069076806 hasConcept C169760540 @default.
- W2069076806 hasConcept C2777426553 @default.
- W2069076806 hasConcept C2778609137 @default.
- W2069076806 hasConcept C2780876595 @default.
- W2069076806 hasConcept C36823959 @default.
- W2069076806 hasConcept C529278444 @default.
- W2069076806 hasConcept C54355233 @default.
- W2069076806 hasConcept C7821365 @default.
- W2069076806 hasConcept C86803240 @default.
- W2069076806 hasConcept C95444343 @default.
- W2069076806 hasConceptScore W2069076806C102230213 @default.
- W2069076806 hasConceptScore W2069076806C104317684 @default.
- W2069076806 hasConceptScore W2069076806C141035611 @default.
- W2069076806 hasConceptScore W2069076806C153911025 @default.
- W2069076806 hasConceptScore W2069076806C169760540 @default.
- W2069076806 hasConceptScore W2069076806C2777426553 @default.
- W2069076806 hasConceptScore W2069076806C2778609137 @default.
- W2069076806 hasConceptScore W2069076806C2780876595 @default.
- W2069076806 hasConceptScore W2069076806C36823959 @default.
- W2069076806 hasConceptScore W2069076806C529278444 @default.
- W2069076806 hasConceptScore W2069076806C54355233 @default.
- W2069076806 hasConceptScore W2069076806C7821365 @default.
- W2069076806 hasConceptScore W2069076806C86803240 @default.
- W2069076806 hasConceptScore W2069076806C95444343 @default.
- W2069076806 hasIssue "24" @default.
- W2069076806 hasLocation W20690768061 @default.
- W2069076806 hasLocation W20690768062 @default.
- W2069076806 hasLocation W20690768063 @default.
- W2069076806 hasLocation W20690768064 @default.
- W2069076806 hasOpenAccess W2069076806 @default.
- W2069076806 hasPrimaryLocation W20690768061 @default.
- W2069076806 hasRelatedWork W1968845441 @default.
- W2069076806 hasRelatedWork W1991389926 @default.
- W2069076806 hasRelatedWork W2010912941 @default.
- W2069076806 hasRelatedWork W2015986188 @default.
- W2069076806 hasRelatedWork W2027069821 @default.
- W2069076806 hasRelatedWork W2027130349 @default.
- W2069076806 hasRelatedWork W2046313016 @default.
- W2069076806 hasRelatedWork W2064416966 @default.
- W2069076806 hasRelatedWork W2334784136 @default.
- W2069076806 hasRelatedWork W2989741672 @default.
- W2069076806 hasVolume "91" @default.
- W2069076806 isParatext "false" @default.
- W2069076806 isRetracted "false" @default.
- W2069076806 magId "2069076806" @default.
- W2069076806 workType "article" @default.