FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069078326> ?p ?o ?g. }

• W2069078326 endingPage "414" @default.
• W2069078326 startingPage "403" @default.
• W2069078326 abstract "In vitro and in vivo studies suggest that the basolateral membrane of choroid plexus cells, which is in contact with blood vessels, is involved in the uptake of the reduced form of vitamin C, ascorbic acid (AA), through the sodium-vitamin C cotransporter, (SVCT2). Moreover, very low levels of vitamin C were observed in the brains of SVCT2-null mice. The oxidized form of vitamin C, dehydroascorbic acid (DHA), is incorporated through the facilitative glucose transporters (GLUTs). In this study, the contribution of SVCT2 and GLUT1 to vitamin C uptake in human choroid plexus papilloma (HCPP) cells in culture was examined. Both the functional activity and the kinetic parameters of GLUT1 and SVCT2 in cells isolated from HCPP were observed. Finally, DHA uptake by GLUT1 in choroid plexus cells was assessed in the presence of phorbol-12-myristate-13-acetate (PMA)-activated human neutrophils. A marked increase in vitamin C uptake by choroid plexus cells was observed that was associated with superoxide generation and vitamin C oxidation (bystander effect). Thus, vitamin C can be incorporated by epithelial choroid plexus papilloma cells using the basolateral polarization of SVCT2 and GLUT1. This mechanism may be amplified with neutrophil infiltration (inflammation) of choroid plexus tumors. In choroid plexus papilloma cells, the vitamin C transporters SVCT2 and GLUT1 are polarized to the basolateral epithelial membrane, where SVCT2 is essential for AA flux from the blood vessels into the brain. However, neutrophils, attracted by inflammation or the tumor microenvironment, can oxidize extracellular AA to DHA, thereby enabling its uptake through GLUT1. For the first time, we show the in vivo and in vitro basolateral co-distribution of functional SVCT2 and GLUT1 in epithelial cells. We postulate that patients with choroid plexus papillomas may continue to transport vitamin C from the blood to CSF. However, increased transport of oxidized vitamin C could generate pro-oxidative conditions that may help control tumor growth." @default.
• W2069078326 created "2016-06-24" @default.
• W2069078326 creator A5005951450 @default.
• W2069078326 creator A5023132884 @default.
• W2069078326 creator A5030556066 @default.
• W2069078326 creator A5052159223 @default.
• W2069078326 creator A5056625339 @default.
• W2069078326 creator A5069447695 @default.
• W2069078326 creator A5071027955 @default.
• W2069078326 creator A5071477774 @default.
• W2069078326 creator A5086751518 @default.
• W2069078326 date "2013-05-29" @default.
• W2069078326 modified "2023-10-17" @default.
• W2069078326 title "Human choroid plexus papilloma cells efficiently transport glucose and vitamin C" @default.
• W2069078326 cites W1480115800 @default.
• W2069078326 cites W1517698775 @default.
• W2069078326 cites W1542691236 @default.
• W2069078326 cites W1553733060 @default.
• W2069078326 cites W1591265240 @default.
• W2069078326 cites W159669330 @default.
• W2069078326 cites W1898796296 @default.
• W2069078326 cites W1966010417 @default.
• W2069078326 cites W1966884697 @default.
• W2069078326 cites W1967207164 @default.
• W2069078326 cites W1978191221 @default.
• W2069078326 cites W1981166466 @default.
• W2069078326 cites W1986970678 @default.
• W2069078326 cites W1991563020 @default.
• W2069078326 cites W1995554804 @default.
• W2069078326 cites W1995825628 @default.
• W2069078326 cites W1996656661 @default.
• W2069078326 cites W1997382203 @default.
• W2069078326 cites W1999334945 @default.
• W2069078326 cites W1999375069 @default.
• W2069078326 cites W2000956051 @default.
• W2069078326 cites W2002184151 @default.
• W2069078326 cites W2005413052 @default.
• W2069078326 cites W2018296945 @default.
• W2069078326 cites W2022344041 @default.
• W2069078326 cites W2023887385 @default.
• W2069078326 cites W2024982524 @default.
• W2069078326 cites W2042967985 @default.
• W2069078326 cites W2049734802 @default.
• W2069078326 cites W2051802738 @default.
• W2069078326 cites W2051964275 @default.
• W2069078326 cites W2052656727 @default.
• W2069078326 cites W2053517647 @default.
• W2069078326 cites W2055628878 @default.
• W2069078326 cites W2056737787 @default.
• W2069078326 cites W2058618870 @default.
• W2069078326 cites W2062526133 @default.
• W2069078326 cites W2064581915 @default.
• W2069078326 cites W2073482726 @default.
• W2069078326 cites W2074034640 @default.
• W2069078326 cites W2074783201 @default.
• W2069078326 cites W2074869909 @default.
• W2069078326 cites W2077538054 @default.
• W2069078326 cites W2079405203 @default.
• W2069078326 cites W2082664913 @default.
• W2069078326 cites W2095081648 @default.
• W2069078326 cites W2099271969 @default.
• W2069078326 cites W2111158723 @default.
• W2069078326 cites W2145066536 @default.
• W2069078326 cites W2404727574 @default.
• W2069078326 cites W4236847248 @default.
• W2069078326 cites W4238040531 @default.
• W2069078326 cites W4240708616 @default.
• W2069078326 cites W4255743371 @default.
• W2069078326 cites W4376595338 @default.
• W2069078326 doi "https://doi.org/10.1111/jnc.12295" @default.
• W2069078326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23647458" @default.
• W2069078326 hasPublicationYear "2013" @default.
• W2069078326 type Work @default.
• W2069078326 sameAs 2069078326 @default.
• W2069078326 citedByCount "20" @default.
• W2069078326 countsByYear W20690783262014 @default.
• W2069078326 countsByYear W20690783262015 @default.
• W2069078326 countsByYear W20690783262016 @default.
• W2069078326 countsByYear W20690783262017 @default.
• W2069078326 countsByYear W20690783262019 @default.
• W2069078326 countsByYear W20690783262020 @default.
• W2069078326 countsByYear W20690783262021 @default.
• W2069078326 countsByYear W20690783262022 @default.
• W2069078326 countsByYear W20690783262023 @default.
• W2069078326 crossrefType "journal-article" @default.
• W2069078326 hasAuthorship W2069078326A5005951450 @default.
• W2069078326 hasAuthorship W2069078326A5023132884 @default.
• W2069078326 hasAuthorship W2069078326A5030556066 @default.
• W2069078326 hasAuthorship W2069078326A5052159223 @default.
• W2069078326 hasAuthorship W2069078326A5056625339 @default.
• W2069078326 hasAuthorship W2069078326A5069447695 @default.
• W2069078326 hasAuthorship W2069078326A5071027955 @default.
• W2069078326 hasAuthorship W2069078326A5071477774 @default.
• W2069078326 hasAuthorship W2069078326A5086751518 @default.
• W2069078326 hasConcept C126322002 @default.
• W2069078326 hasConcept C134018914 @default.
• W2069078326 hasConcept C161573976 @default.
• W2069078326 hasConcept C185592680 @default.

• next